922例无精子症患者的病因诊断及其意义  

The etiological diagnosis of 922 patients with azoospermia

作　　者：费前进[1] 黄学锋[1] 李澄棣[1] 张李雅[1] 杨旭[1] 

机构地区：[1]浙江省温州医学院附属第一医院生殖医学中心,温州325000

出　　处：《生殖医学杂志》2009年第2期119-122,共4页Journal of Reproductive Medicine

摘　　要：目的探讨无精子症患者的病因。方法对922例无精子症患者按WHO标准进行病因诊断分析。结果922例无精子症患者中先天性异常445例(48.3%)、特发性无精子症206例(22.3%)、梗阻性无精子症198例(21.5%)、医源性疾病26例(2.8%)、获得性睾丸损伤23例(2.5%)、全身性疾病10例(1.1%)、精索静脉曲张8例(0.9%)、内分泌病因6例(0.7%);206例特发性无精子症患者睾丸活检结果,睾丸生精功能低下38例(18.4%)、生精阻滞69例(33.5%)、唯支持细胞综合征(SCOS)90例(43.7%)、生精小管透明变性9例(4.4%)。结论先天性异常、特发性无精子症和梗阻性无精子症是无精子症患者的主要病因,SCOS是特发性无精子症患者睾丸生精障碍的主要病理类型。Objective.To investigate the etiology of the patients with azoospermia. Methods：Nine hundred and twenty-two patients with diagnosed azoospermia were classified according to the WHO manual. Results：Of 922 patients, 445 were diagnosed as congenital abnormalities （48.3%）, 206 as idiopathic azoospermia （22.3%）, 198 as obstructive azoospermia （21.5%）, 26 as iatrogenic causes （2.8%）, 23 as acquired testicular damage （2. 5%）, 10 as systemic causes （1. 1%）, 8 as varicocele （0. 9%）, and 6 as endocrine causes （0. 7%）. Testicular biopsy was performed on 206 patients diagnosed with idiopathic azoospermia, and the histopathological results showed that there were 38 patients （18. 4%） with hypospermatogenesis, 69 （33.5%） with maturation arrest, 90 （43.7%） with Sertoli cell-only syndrome （SCOS） and 9 （4.4%） with seminiferous tubule hyalinization. Conclusions： Congenital abnormalities, idiopathic azoospermia and obstructive azoospermia were the main causes of azoospermia, and the main testicular problem in the patients with idiopathic azoospermia was SCOS.

关 键 词：男性 无精子 病因 

分 类 号：R512.1[医药卫生—内科学] R441.7[医药卫生—临床医学]