PDZ连接激酶/T-LAK细胞源蛋白激酶研究进展  

Progress in research of PDZ-binding-kinase/T-LAK cell-originated protein kinase

作　　者：张安平[1] 刘宝华[1] 

机构地区：[1]中国人民解放军第三军医大学大坪医院野战外科研究所普通外科,重庆市400042

出　　处：《世界华人消化杂志》2009年第9期901-905,共5页World Chinese Journal of Digestology

摘　　要：PDZ连接激酶/T-LAK细胞源蛋白激酶(PDZ-binding-kinase/T-LAKcell-originated protein kinase,PBK/TOPK)是一种新近发现的丝-苏氨酸激酶,具有参与调控恶性肿瘤细胞的增殖和周期变化,促进肿瘤细胞转化,并且通过MAPKK信号通路参与调控细胞DNA损伤修复.特别是近期发现其具有强烈的细胞恶性诱导潜能而可能成为新的肿瘤治疗靶点.PDZ-binding-kinase/T-LAK cell-originated protein kinase （PBK/TOPK） is a recently identified 322-amino acid serine/threonine kinase involved in cell cycle and proliferative regulation of malignant cells. PBK/TOPK promotes tumor cell proliferation through p38 MAPK activity and regulation of the DNA damage repair response. New studies indicate that PBK/TOPK have a important potential to induce malignant transformation, suggesting a potential target for chemotherapeutic treatment of cancer.

关 键 词：PDZ连接激酶/T-LAK细胞源蛋白激酶 MAPKK 丝-苏氨酸激酶 

分 类 号：R341[医药卫生—基础医学]