甲硝唑/蒙脱土抗菌复合物的制备及体外缓释特征  

Preparation of Metronidazole/MMT antibacterial composite and in vitro release characteristics

作　　者：杨建华[1] 路新卫[2] 韦莉萍[1] 丁婷[1] 

机构地区：[1]南方医科大学中医药学院,广东省广州市510515 [2]南方医科大学药学院,广东省广州市510515

出　　处：《世界华人消化杂志》2009年第9期914-917,共4页World Chinese Journal of Digestology

基　　金：广州市科技攻关计划基金资助项目;No.2004Z3-E0171;广东省卫生厅医学科研基金资助项目;No.A2004411~~

摘　　要：目的:研究甲硝唑/蒙脱土抗菌复合物的制备及其体外释放特性.方法:以离子交换方式将甲硝唑插层到钠基蒙脱土的层间,通过XRD、FTIR及TG对抗菌复合物的性能进行表征,并通过体外释放试验检测缓释效果.结果:插层后,钠基蒙脱土层间距由1.2345nm增大到1.3026nm,说明甲硝唑已经插入钠基蒙脱土层间;通过体外释放试验检测证实抗菌复合物具有良好的缓释效果.结论:甲硝唑/蒙脱土抗菌复合物具有缓释作用,可进一步开发成抗感染缓释药物.AIM： To prepare a Metronidazole/MMT antimicrobial composite and study its in vitro release characteristics. METHODS： Metronidazole is intercalated into the interlayer of Na-MMT with ion-exchange. Metronidazole/MMT was analyzed by XRD, FTIR and TG, and its release characteristics was detected by in vitro release experiment. RESULTS： The interlayer space of Metroni- dazole/MMT has increased to 1.3026 nm from 1.2345 nm, showing that Metronidazole has already been intercalated into the interlayer of Na-MMT. In vitro experiment demonstrated that Metronidazole/MMT antimicrobial composite had a good characteristic of sustained-release. CONCLUSION： Metronidazole/MMT antimi- crobial composite with sustained-release prop- erty can be further developed into a sustained- release anti-infection drugs.

关 键 词：甲硝唑 抗菌复合物 缓释 钠基蒙脱土 

分 类 号：R944[医药卫生—药剂学] TQ460.1[医药卫生—药学]