滴鼻灵对变应性鼻炎患者血清IL-5和鼻分泌物嗜酸性粒细胞的影响  

Effect of Dibiling Nasal Drops on IL-5 level in serum and eosinophils number in nasal secretion among patients with allergic rhinitis

作　　者：钟彦[1] 高士俊[1] 宋若会[1] 刘钢[1] 屠彦红[1] 吴飞虎[1] 金龙[1] 

机构地区：[1]安徽中医学院第一附属医院耳鼻咽喉科

出　　处：《中国中西医结合耳鼻咽喉科杂志》2009年第2期68-70,共3页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：安徽省教育厅科研基金资助项目(2003KJ235)

摘　　要：目的观察滴鼻灵滴鼻液对变应性鼻炎患者血清白细胞介素-5水平及鼻腔分泌物嗜酸性粒细胞数量的影响。方法变应性鼻炎患者28例，予滴鼻灵滴鼻液治疗2周，记录治疗前后症状、体征的变化，同时检测治疗前后血清IL-5水平，行鼻腔分泌物嗜酸性粒细胞计数，并与正常对照组22例进行比较，分析其疗效相关性及意义。结果疗程结束时评价疗效，本组患者显效25例，有效2例，无效1例，总有效率96．4％。治疗前，患者血清IL-5水平及鼻腔分泌物嗜酸性粒细胞计数均较正常对照组显著升高（P〈0．01）；经滴鼻灵治疗后，血清IL-5明显下降（P〈0．01），接近正常对照组（P〉0．05），鼻腔分泌物嗜酸性粒细胞明显减少甚至消失。结论滴鼻灵可能通过调控患者机体免疫功能对变应性鼻炎发挥治疗效应。Objective To investigate the effect of Dibiling Nasal Drops （DND） on IL-5 level in serum and eosinophile number in nasal secretion among the patients with allergic rhinitis （AR） based on a clinical trial. Methods Included in this study were 28 cases with AR treated with DND for 2 weeks, with their symptoms and signs recorded, serum level of IL-5 determined and the number of eosinophils counted before and after the therapy respectively. Then, one controlling group composed of 22 healthy persons was set up for comparative analysis on these clinical and laboratory data to explore their correlations with therapeutic effect and the implications in pharmacological mechanisms of DND. Results As evaluated by the end of therapy on the therapeutic effect, 25 were shown significantly effective, 2 effective and only one ineffective, with a total effective rate of 96.14% in this group of patients. Before the therapy, the level of IL-5 in serum and the number of eosinophils in nasal secretion were both significantly higher among cases with AR than that in healthy controls （P 〈0.01）. Following the treatment with DND for 2 weeks, the serum level of IL-5 was significantly declined among these cases （P〈0.01）, nearly approaching to the level of healthy controlling group （P〉0.05）, and the eosinophile number in nasal secretion was also markedly decreased, even disappeared totally. Conclusion DND may give rise its therapeutic effect on AR via regulation on the immune function of patients with this kind of lesion.

关 键 词：滴鼻灵滴鼻液 变应性鼻炎 疗效 药理机制 

分 类 号：R276.1[医药卫生—中医五官科学]