伞形科辛味中药主要化学成分对离体血管作用研究  

The study of vasoactive of pungent herbs' chemical constituents in Umbelliferae

作　　者：李振坤[1,2] 刘玫琦[2] 杨洪军[2] 

机构地区：[1]江西中医学院,南昌330004 [2]中国中医科学院中药研究所,北京100700

出　　处：《中药药理与临床》2009年第1期38-40,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金项目(30600820);国家重点基础研究发展计划(2006CB504700);国家自然科学基金项目(30472143)

摘　　要：目的:观察伞形科辛味中药主要化学成分对离体血管的舒张作用。方法:采用大鼠离体主动脉环模型,分别观察蛇床子素、阿魏酸钠、积雪草苷、茴香醛、藁本内酯、丁基苯酞、白花前胡丙素、欧前胡素、异欧前胡素、α-细辛醚等10种化合物,对离体血管的舒张作用。结果:蛇床子素、欧前胡素、异欧前胡素、白花前胡丙素、细辛醚、丁基苯酞的舒张血管活性强于川芎嗪,藁本内酯、茴香醛与川芎嗪相当,阿魏酸钠、积雪草苷活性弱于川芎嗪。结论:药典收载的伞形科辛味中药均具有舒张血管作用。Objective ：To observe the vasorelaxation effect of pungent herbs＇chemical constituents in Umbelliferae. Methods ：The vasorelaxation effect of 10 compounds was observed by isolated vascular rings model . Results ：The results showed that the vasorelaxation effect of 6 compounds （ osthole, imperatorin, isoimperatorin, praeruptorin, asarone, butylphthalide ） were stronger than tetramethylpyrazine. The vasorelaxation effect of ligustilide and anisaldehyde suitable to tetramethylpyrazine. The vasorelaxation effect of fendic acid sodium and asiatieoside were less than tetramethylpyrazine. Conclusion ： vasorelaxation effect is one of the generic pharmacological activity of pungent herbs in Umbelliferae.

关 键 词：中药药性 伞形科 化学成分 血管活性 

分 类 号：R285[医药卫生—中药学]