重组人表皮生长因子加速皮肤创伤修复的实验研究  

A Study of recombined human epidermal growth factor (rhEGF) improving experimental wound healing

作　　者：郝杰[1] 彭波[2] 杨云霞[1] 包旭[1] 朱玲[1] 冯云[3] 范爱兰[1] 

机构地区：[1]四川大学华西医学中心药理教研室,成都610041 [2]中山大学生命科学院动物生理教研室,广州510275 [3]四川大学华西医学中心感染免疫室,成都610041

出　　处：《中国美容医学》2009年第B03期46-48,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:观察局部应用重组人表皮生长因子(recombined human epidermal growth factor,rhEGF)对大鼠皮肤深Ⅱ度烫伤以及家兔皮肤切割伤愈合有无促进作用。方法:建立约10的大鼠烫伤面积和长约10cm家兔切割伤后,测定给不同剂量的rhEGF治疗后不同时间的烫伤创面愈合面积,创伤组织的病理组织学以及测定愈合时间来观察rhEGF对皮肤创伤的治疗作用。结果:rhEGF小、中、大剂量(每cm_2创面200IU,400IU,800IU)可以缩短大鼠皮肤深Ⅱ度烫伤和家兔皮肤切割伤愈合的时间,同一时间内大鼠烫伤愈合面积高于对照组,同时还可以增加表皮细胞和毛细血管的增生,三个剂量之间未见明显的剂量依赖性。Objective The effect of the topical application of recombined human epidermal growth factor （rhEGF） on wound healing was evaluated. Methods After topical the treatment of rhEGF,the healing areas, and cell growth were measured. Results Topical application of rhEGF to rat or rabbit wound deceased the time to complete healing, accelerated epithelial and capillary hyperplasia. The healing areas were observed increasing in rat scald wound. Conclusion We were able to demonstrate an insignificant healing advantage with the topical application of rhEGF.

关 键 词：重组人表皮细胞生长因子 烫伤 切割伤 愈合 

分 类 号：R644[医药卫生—外科学] R362[医药卫生—临床医学]