蒙特利尔认知评估量表在轻度认知功能障碍筛查中的应用  

Application of Montreal Cognitive Assessment in screening mild cognitive impairment in elderly patients

作　　者：李海员[1] 王延平[1] 黄绍宽 杨少青[1] 陈盛强[1] 邓永萍 陈智超 

机构地区：[1]广州医学院附属第二医院神经内科,广州510260 [2]广州市老人院,510550

出　　处：《中华神经医学杂志》2009年第4期376-379,共4页Chinese Journal of Neuromedicine

摘　　要：目的探讨蒙特利尔认知评估量表（MoCA）在轻度认知功能障碍（MCI）患者筛查中的应用。方法应用简易精神状态检查量表（MMSE）、MoCA对32例MCI患者和50例健康对照者进行神经心理评估，比较二者筛查MCI的效果。结果以26分为分界值，MoCA筛查MCI的敏感性为96．87％、特异性为76％，MMSE筛查MCI的敏感性为56．25％、特异性为96％；MoCA中除抽象思维、地点定向两项外，其余各亚项的评分在MCI组和对照组间差异均有统计学意义（P〈0．05）；MMSE中仅计算与注意力、延迟回忆两项在MCI组和对照组间差异有统计学意义（P〈0．05），其余各项差异均无统计学意义（P〉0．05）。结论MoCA为高敏感性的MCI筛查工具，能全面评估MCI患者的认知功能，且可用于筛查MMSE得分正常的MCI患者。Objective To assess the value of Montreal Cognitive Assessment （MoCA） in screening mild cognitive impairment （MCI） in elderly patients. Methods Thirty-two elderly patients with MCI and 50 healthy elderly subjects were examined with neuropsychological tests using Mini-mental State Examination （MMSE） and the MoCA. Results With a cut-off score of 26, the MoCA had a sensitivity of 96.87% and specificity of 76% for detecting MCI, and the sensitivity and specificity of MMSE were 56.25% and 96%, respectively. For the MoCA sub-items, the elderly patients with MCI had significantly lower scores than the healthy elderly in all the cognitive function measures （P〈0.05） except for abstraction and fixed orientation. In MMSE sub-items, significant differences were found between the two groups in only calculation/attention and delayed recall （P〈0.05）. Conclusions The MoCA is a highly sensitive scale for screening MCI in elderly patients, which allows comprehensive assessment of the cognitive function of MCI patients and is applicable in detecting MCI in patients with normal MMSE results.

关 键 词：轻度认知功能障碍 蒙特利尔认知评估量表 

分 类 号：R686[医药卫生—骨科学]