颈动脉内膜-中层厚度与载脂蛋白基因多态性  

The association of carotid arterial intima media thickness with polymorphism of apolipoprotein genes

作　　者：叶平[1] 尚延忠[1] 王节[1] 杨丙建[1] 

机构地区：[1]解放军总医院

出　　处：《实用老年医学》1998年第1期22-24,共3页Practical Geriatrics

摘　　要：目的探讨老年人颈动脉内膜－中层厚度（ＩＭＴ）与载脂蛋白基因多态性，及其与多种心血管病危险因素的关系。方法采用分子生物学方法测定６２例中老年人载脂蛋白Ｂ（ａｐｏＢ）和载脂蛋白Ｅ（ａｐｏＥ）的基因多态性，并用高分辨率Ｂ型超声检测ＩＭＴ。结果不同的ａｐｏＥ和ａｐｏＢ等位基因型之间颈动脉ＩＭＴ及血脂质水平均无明显的差异。多因素逐步判别分析发现，年龄、高血压病和收缩期血压与颈动脉ＩＭＴ呈显著的正相关性（ｒ＝０．４２２，０．４８１，０．５４２，Ｐ＜０．０１）。ＩＭＴ增加者（≥１．０ｍｍ）冠心病和脑梗塞的发生率明显高于ＩＭＴ正常者（＜１．０ｍｍ）。结论ａｐｏＥ和ａｐｏＢ基因多态性对老年人颈动脉ＩＭＴ增加及血脂质水平变化无明显的影响。衰老和高血压不同程度地影响老年人的颈动脉ＩＭＴ。bjective To investigate the association of carotid arterial intima media thickness (IMT) with polymorphism of apolipoprotein E and B genes,and with various risk factors for cardiovascular disease in elderly subjects. Methods Polymorphism of the apolipo protein B and apolipoprotein E gene was determined by PCR and restrictive enzyme cleavage,and carotid arterial IMT was measured by high resolusion B mode ultrasound in a total of 62 subjects. Results Carotid IMT and lipid levels were not significantly different between different apo E alleles and differnt apo B alleles.Age,hypertension and systolic blood pressure were positively correlated with carotid IMT on multiple stepwise regression analysis ( r =0 422,0 481 and 0 542 respectively, P <0 01).The incidences of coronary heart disease and cerebral infarction were significantly higher in subjects with IMT≥1 0mm than those with IMT≤1 0mm( P <0 05～0 01). Conclusions Carotid arterial IMT and blood lipid levels are not associated with polymorphism of apolipoprotein B and E genes in the elderly population.Aging and hypertension have effect on carotid IMT to some extent.

关 键 词：基因 多态性 颈动脉 动脉粥样硬化 载脂蛋白 

分 类 号：R543.502[医药卫生—心血管疾病]