HTG、A-TG、A-TPO联合检测在甲状腺疾病诊断中价值  

The Combined Detection of HTG、A-TG and A-TPO's value in thyroid diseases diagnosis

作　　者：朱杰[1] 王善菊[1] 常青燕 

机构地区：[1]大连医科大学第二临床学院检验科,辽宁大连116027 [2]大连市第六人民医院药剂科,辽宁大连116021

出　　处：《中国实验诊断学》2009年第4期510-513,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清甲状腺球蛋白(HTG)、抗甲状腺球蛋白抗体(A-TG)和抗甲状腺过氧化物酶抗体(A-TPO)变化对甲状腺疾病的价值及其相互关系。方法以电化学发光免疫方法检测不同甲状腺疾病患者血清甲状腺球蛋白(HTG)、抗甲状腺球蛋白抗体(A-TG)和抗甲状腺过氧化物酶抗体(A-TPO)水平,进行统计学分析。结果正常对照组血清HTG、A-TG和A-TPO分别为(22.72±20.31)ng/ml(、47.72±31.07)IU/ml、(20.59±15.07)IU/ml,在甲状腺癌和亚急性甲状腺炎中血清HTG显著增高,分别为(225.21±267.74)ng/ml(、432.40±323.44)ng/ml,P<0.01,其他疾病组血清HTG无显著差异,桥本氏甲状腺炎中A-TG、A-TPO与其他各疾病组(亚急性甲状腺炎、结节性甲状腺肿和甲状腺癌)和正常组比较显著增高,分别为(599.17±1068.64)IU/ml(、292.92±196.50)IU/ml,P<0.01,且总阳性率最高,且A-TPO的阳性率(100%)要高于A-TG(52%),其他各疾病组与对照组比较也有不同程度的增高。结论HTG可作为甲状腺癌手术后复发转移观察指标,对甲癌和其他良性甲状腺疾病渐被诊断的有一定的价值;血清A-TG和A-TPO在大多数甲状腺自身免疫性疾病的诊断中,联合检测具有更高的临床价值,对自身免疫性甲状腺疾病的发病机制,协助和完善甲状腺疾病的诊断和鉴别诊断以及指导临床治疗均有一定的临床意义。Objective To study change of serum HTG, A-TG and A-TPO＇ s value in thyroid disease and their mutual relation- ship.Methods Serum HTG,A-TG and A-TPO level of different kinds of thyroid diseases patients were measured by electrochemical luminescence immunoassay. The results were analyzed statistically. Results Sermn HTG, A-TG and A-TPO of normal control group were respectively （22.72 ± 20.31）ng/ml, （47.72 ± 31.07）IU/ml, （20.59 ± 15.07） IU/ml. Serum HTG of thyroid cancers and subacute thyroiditis increase significantly, respectively （225.21 ± 267.74） ng/ml, （432.40 ± 323.44） ng/ml, P 〈 0.01. H-TG of other diseases group bad no evident difference. A-TG and A-TPO of Hashimoto＇ s diseases increased significantly compared with other diseases group, （subacute thyroiditis, nodal struma and thyroid cancer and normal control）, respectively （599.17 ± 1068.64）IU/ml, （292.92 ± 196.50）IU/ml, P 〈 0.01 .Total positivity rate of Hashimoto＇ s diseases Was highest. A-TPO＇ s positivity rate was 100%, higher than that of A-TG （52%）. A-TG and A-TPO of other diseases group were higher indifferent degree than normal control. Conclusion HTG can act as observation index of relapse and transfer after thyroid cancer operation. It has a certain significance in differentiation diagnosis of thyroid cancer and other benign thyroid diseases. A-TG and A-TPO can be refered in diagnosing most auto-immane diseases of thyroid. Their combined detection has higher clinical value. They have clinical significance in studying diseases onset mechanism of auto-immue thyroid diseases, helping and cosummating diagnosis and differentiation diagnosis of thyroid diseases, and instructing clinical treatment.

关 键 词：HTG A-TG A-TPO 甲状腺疾病 

分 类 号：R581[医药卫生—内分泌] R446.6[医药卫生—内科学]