佩尔地平治疗早发型重度子痫前期临床研究  

Clinical research on the impact of perdipine to cure early onset severe preeclampsia

作　　者：肖冰莲[1] 尹国武[2] 李秀萍[1] 李怡[2] 杨艳红[2] 杨华光[2] 

机构地区：[1]陕西省西安市第四医院妇产科,西安710004 [2]第四军医大学唐都医院妇产科

出　　处：《临床医学》2009年第4期1-3,共3页Clinical Medicine

摘　　要：目的探讨佩尔地平对早发型重度子痫前期患者的血流动力学及血清Ca2+、Mg2+浓度的影响。方法将133例早发型重度子痫前期患者随机分为两组:A组(佩尔地平治疗组)66例;B组(酚妥拉明治疗组)67例。分别于治疗前后检测血压,血清Ca2+、Mg2+浓度和尿蛋白的变化等。结果①血压变化:各组治疗后收缩压、舒张压比治疗前均有所下降,以收缩压下降为主,其中A组下降尤为显著,与B组比较差异有统计学意义(P<0.05)。A组用药后3 d达到显效水平,而B组为用药后4 d,同时发现B组出现2例顽固性高血压患者,发生率为2.99%。②血清Ca2+、Mg2+浓度的变化:各组治疗后血清Ca2+、Mg2+浓度均有升高,治疗前后比较差异有统计学意义(P<0.05);而组间比较差异无统计学意义(P>0.05)。③两组尿蛋白下降比较:两组24 h尿蛋白定量均有下降,治疗前后比较差异有统计学意义(P<0.05),组间比较差异无统计学意义(P>0.05)。④妊娠结局:A组平均维持妊娠时间较B组显著延长(P<0.05),胎儿Apgar评分A组优于B组,两组产后出血量、新生儿体重比较差异无统计学意义(P>0.05)。结论佩尔地平配合硫酸镁治疗早发型重度子痫前期,不但疗效肯定,可能对顽固性高血压也有一定的疗效,值得推广应用。Objective To explore the impact of perdipine to haemodynamics and the concentration with serum Ca^2 ＋ , Mg^2＋ in the early onset severe preeclampsia. Methods Early onset severe preeclampsia were randomly divided into two groups： group A （perdipine treatment group） of 66 cases; Group B（ phentolamine treatment group） of 67 cases. Testing before and after treatment in blood pressure, serum Ca^2＋ , Mg^2＋ concentration and protein in urine changing, and so on. Results ①Changes in blood pressure ： systolic blood pressure and diastolic blood pressure decrease before and after treatment in each group, mainly in systolic blood pressure decreased, the decline of group A was particularly significant, group A with significant differences compared with group B （ P 〈 0. 05 ）. Group A reach the level of effect after 3 days, while group B after treatment for 4 days. Group B had found 2 cases of resistant hypertension patients, the incidence rate of 2.99 percent.②Serum Ca^2＋ , Mg^2＋ concentration changes： in each group after treatment serum Ca^2＋ , Mg^2＋ concentration have increased, the difference between before and after treatment was significantly （ P 〈0.05）; and the control group with no significant difference （ P 〉 0.05 ）. ③Compared urinary protein declined： total volume urine protein decrease in each group, before and after therapy the two group had statistical significance （ P 〈 0. 05 ）, the control group with no significant group difference （ P 〉0. 05 ）. ④Pregnancy outcome ： the average gestation time of group A was significantly increased than that in group B （ P 〈 0.05 ） , and fetal Apgar score group A was better than group B, two groups of postpartum hemorrhage, birth weight had no significant difference. Conclusion Perdipine with magnesium sulfate not only has affirmative curative effect in the treatment of early onset severe preeclampsia, but also has some effect on resistant hypertension. It is deserved to be applied.

关 键 词：妊娠 子痫前期 早发型 佩尔地平 

分 类 号：R714.245[医药卫生—妇产科学] R544.1[医药卫生—临床医学]