以水为溶剂合成α-溴代-邻(对)氯苯乙酮的研究  

Synthesis of α-Bromo-o(p)-chloroaetophenone with Water as Solvent

作　　者：张书文[1] 路红凯[1] 张志平[1] 

机构地区：[1]河北大学化学与环境科学学院,河北保定071002

出　　处：《化学世界》2009年第4期238-240,共3页Chemical World

摘　　要：以溴为溴化剂,在水中进行邻(对)氯苯乙酮α-氢的溴代反应,合成了α-溴代邻(对)氯苯乙酮。通过实验确定并优化了工艺条件,其最佳工艺条件为:n(氯代苯乙酮)∶n(溴)=1∶1.1;反应温度为室温;反应时间为3～4h;收率可达91.2%(92.4%)。本工艺方法的特点是:(1)不使用任何有机溶剂,对环境无污染,属于环境友好型工艺;(2)常温反应无需加热,节约能源;(3)操作简单,生产成本低,适合于规模化生产。α-Bromo-o （ p ）-chloroacetophenone was synthesized by α-bromization of 2 （ 4 ）-chl- oroacetophenone with water as solvent and bromine as bromizating agent. The reaction conditions of α- bromization were studied. The optimal conditions were as follows： molar ratio of o（p） -chloroacetophenone and bromine, 1 ： 1.1 ; ambent temperature; reaction time of 3-4 h. Under the optimum conditions, the yield was 91.2%（92.4%）. This technology does not use organic solvent and does not cause pollution to the environment, so it belongs to the environment friendly green chemical technology.

关 键 词：α-溴代邻氯苯乙酮 α-溴代对氯苯乙酮 溴 水 环境友好 

分 类 号：TQ244.4[化学工程—有机化工]