4-三氟甲氧基苯基-氨基甲酸甲酯的催化合成  

Catalytic Synthesis of 4-Trifluoromethoxy Phenyl Carbamate

作　　者：余生[1] 胡新根[1] 朱玉青[1] 陈帆[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325027

出　　处：《化学世界》2009年第4期244-246,233,共4页Chemical World

基　　金：浙江省科技厅绿色化工技术重大科技专项重点项目(2006C11025)

摘　　要：常压下,从4-三氟甲氧基苯胺出发,以碳酸二甲酯(DMC)为甲氧羰基化试剂,在不添加其他任何辅助试剂条件下催化合成4-三氟甲氧基苯基氨基甲酸甲酯(TFMPC)。系统研究了负载型和非负载型催化剂、反应温度、反应时间对合成的影响,发现ZrClO2/SiO2在后处理和催化剂再生方面均比Zn(OAc)2/SiO2效果要好,同时在最佳工艺条件下可以得到较好的反应转化率和产品收率。A catalytic methoxycarbonylation route under atmospheric pressure to 4-trifluoromethoxy phenyl earbamate （TFMPC） from 4-（trifluoromethoxy）benzenamine and dimethyl carbonate （DMC） was demonstrated. The effect of various factors including variety of supported and unsupported catalysts, reaction temperature and time were investigated. It was shown that ZrClO2/SiO2 was better than ZnOAc/ SiO2 with regard to catalyst regeneration and post-processing of product. The optimal reaction conditions for high conversion rate and good yield of TFMPC were obtained.

关 键 词：4-三氟甲氧基苯胺 碳酸二甲酯(DMC) 4-三氟甲氧基苯基氨基甲酸甲酯(TFMPC) 负载型催化剂 催化合成 

分 类 号：O643[理学—物理化学]