黄竹清脑颗粒对痰热腑实证脑出血急性期大鼠血清MDA及血浆TNF-α的影响  

Effect of MDA In serum and TNF-α In Plasma by Huangzhuqingnao Pellet on The Acute Intracerebral Hemorrhage Rat

作　　者：刘淑霞[1] 任惠锋[1] 石春明[1] 白雅[1] 

机构地区：[1]陕西中医学院,咸阳712046

出　　处：《江西中医学院学报》2009年第2期62-64,共3页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：陕西省教育厅专项科研基金项目(07JK224)

摘　　要：目的:探讨黄竹清脑颗粒对脑出血急性期大鼠血清中MDA及血浆中TNF-α的影响。方法:70只SD大鼠随机分为空白组、模型组、二陈汤组、鲜竹沥组、黄竹清脑颗粒大、中、小剂量组,造模成功后,开始灌胃给药,日1次,连续7d。然后抽取血样,测定血清中MDA及血浆中TNF-α的含量。结果:ICH大鼠脑内血肿形成后,动物均有神经系统症状;模型组与空白组相比,血浆中TNF-α及血清中MDA明显升高,提示造模成功;黄竹清脑颗粒大、中剂量明显优于二陈汤组和鲜竹沥组。结论:黄竹清脑颗粒具有抗氧化,抑制炎性反应,保护脑出血急性期脑神经细胞的作用,并对中风病痰热腑实证有明显改善作用。Objective:To research the effect of MDA in serum and TNF-α in plasma by Huang Zhu Qing Nao Pellet(HZQNP)on acute intracerebral hemorrhage(ICH).Method:70 adult male sprapue rats were randomly divided into normal contronl group,model contronl group,er chentang group,xianzhuli group,HZQNP hing-dose trearment group,HZQNP mediate-dose trearment group,HZQNP low-dose trearment group.After model founded successfully,began irrigating medicine into stomach once a day and last 7days.Then the extraction blood sample,measurate MDA content in serum and TNF-α content in plasma.Results:During acute stage of ICH,HZQNP may obviously reduce MDA in serum and TNF-α in plasma of rats with ICH.Conclusion:HZQNP is provided with some function such as peroxidation,repress burning to respond an ect.and protect brain neurocyte.And has the distinct improvement function to the stroke sickness phlegm hot internal organs real diagnosis.

关 键 词：黄竹清脑颗粒 脑出血 丙二醛 肿瘤坏死因子-α 

分 类 号：R285.5[医药卫生—中药学]