正交试验优选酮通颗粒成型工艺  

Optimization of the Forming Technology of Tongtong Granules by Orthogonal Experiment

作　　者：孙兆荣[1] 武夏明[1] 刘逢芹[2] 李宏建[2] 

机构地区：[1]泰山医学院附属医院,泰安市271000 [2]山东千佛山医院,济南市250014

出　　处：《中国药房》2009年第12期907-909,共3页China Pharmacy

摘　　要：目的:优选酮通颗粒的成型工艺。方法:先以吸湿百分率为指标考察辅料的类别及其比例;再采用正交试验,以成型率和吸湿百分率为指标,以提取物与辅料的比例、乙醇浓度、乙醇用量为考察因素,优选成型工艺。结果:以乳糖:糊精=3:2为最佳辅料配比;最佳成型工艺为提取物与辅料按1:2的比例混匀,以70%乙醇为润湿剂制软材,乙醇用量为12%(mL·g^(-1))。成品颗粒的流动性好,临界相对湿度约为70%。结论:该成型工艺可行、稳定合理、重现性较好,可为工业化生产提供理论依据。OBJECTIVE： To optimize the forming technology of Tongtong granules. METHODS： The category and ratio of the adjuvants were optimized taking moisture absorption percentage as index; the forming technology of Tongtong granules was optimized by orthogonal experiment with forming rate and moisture absorption percentage as indexes and with the ratio of extract to adjuvant, the concentration and amount of ethanol as factors. RESULTS： The optimal ratio of lactose to dextrin was 3 ： 2. The optimal forming technology was as follows： the ratio of extract to adjuvant was 1 ： 2; 70% alcohol was used as the wetting agent with its amount at 12% （mL·g^-1） .The Tongtong granules mobility enjoyed good flowability with a critical relative humidity of about 70% . CONCLUTION： The forming technology is feasible, stable, reasonable and reproducible and it serves as theoretic basis for industrial production.

关 键 词：酮通颗粒 成型工艺 正交试验 

分 类 号：R284.2[医药卫生—中药学] R943[医药卫生—中医学]