子宫内膜异位症DNA异常甲基化的研究进展  

Research Progress in DNA Abnormal Methylation of Endometriosis

作　　者：邬俊[1] 周秋明[2] 吴元赭[2] 

机构地区：[1]徐州医学院,221004 [2]南京军区总医院妇产科

出　　处：《国际妇产科学杂志》2009年第2期94-97,共4页Journal of International Obstetrics and Gynecology

摘　　要：DNA甲基化是基因组表观遗传调控重要的方式之一。近年研究发现,DNA甲基化造成的相关基因异常表达在子宫内膜异位症发生发展中有着重要影响,尤其是HOXA10基因的异常甲基化导致其基因表达下降。回顾相关基因异常甲基化与子宫内膜异位症发生、诊断、治疗及预后判断的关系,进一步探讨子宫内膜异位症中可能的分子机制。DNA methylation is one of the main way of epigenetic mechanisms of transcriptional control.In recent years,some reports indicate that aberrant expression of genes result from abnormal DNA methylation of related genes and make an important effect with the initiation and progression of endometriosis ,especially aberrant methylation of HOXA10 gene which cause the down-regulation of its expression.In this review ,we summarized the abnormal methylation of related-genes and its ralationship with endometfiotic pathogenetic processes,diagnosis, therapy and prognosis, and discussed the molecular mechanisms in endometriosis.

关 键 词：子宫内膜异位症 子宫内膜 DNA甲基化 发病机制 CPG岛 

分 类 号：R711.71[医药卫生—妇产科学] R730.231[医药卫生—临床医学]