FW型轴流泵的体外溶血与动物实验研究  

Experimental Study of Hemolysis in Vitro and Animal Testing for Fu Wai Axial Blood Pump

作　　者：张岩[1,2] 胡盛寿[1,2] 周建业[1] 孙寒松[2] 唐跃[2] 郑哲[1,2] 张浩[1,2] 李国荣[2] 朱晓东[2] 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院卫生部心血管病再生医学重点实验室 [2]中国医学科学院中国协和医科大学阜外心血管病医院心血管病研究所心脏外科,北京100037

出　　处：《中国胸心血管外科临床杂志》2009年第2期114-117,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家十一五课题基金资助项目(2003BAI01A00);863课题资助项目(2006AA02Z4D3)~~

摘　　要：目的为给心力衰竭患者提供有效的心室机械辅助治疗,研制出可以部分或完全代替心室功能的FW(FuWai)型轴流式心室辅助血泵,评价其流体力学性能和血液相容性能。方法通过体外测试台和5只小尾寒羊的动物实验,对FW型轴流式心室辅助血泵的流体力学性能和血液相容性能进行了测试。结果轴流泵在转速为8400r/min、后负荷为100mmHg的情况下,流量可达5L/min;体外溶血试验检测结果表明轴流泵的标准溶血指数(NIH)为0.17±0.06mg/L。动物实验结果表明,血浆游离血红蛋白含量在30mg/dl左右。结论FW型轴流式心室辅助血泵的血液相容性能良好,体外和体内试验结果达到了国际标准,有望在完善动物实验的基础上进入临床试验阶段。Objective To provide a ventricular assist device for patients with heart failure, Fu Wai （FW） axial blood pump was developed for partly or totally to assist the left ventricular function. Vitro hemolysis and animals tests were also employed to test the hydromechanics and hemocompatibility of the FW left ventricular assist devices developed in Fu Wai hospital. Methods Using vitro test loop, FW axial blood pump has been used to evaluate the performance of hemolysis, the pump has also been tested for hemolysis characteristic through five sheep experiments. Results At 8 400 r/min, the pump generates 5 L/min flow against 100 mm Hg, the normalized index of hemolysis （NIH） was 0.17±0.06 mg/L. The plasma free hemoglobin of in vivo tests was around 30 mg/dl. Conclusion The results obtained in vitro and in vivo testing indicate an acceptable design for the blood pump, further in vivo tests will be performed before clinical use.

关 键 词：轴流泵 溶血 体外试验 动物试验 标准溶血指数 

分 类 号：R541.6[医药卫生—心血管疾病]