充血性心力衰竭患者外周血单个核细胞核因子-κB活性的变化及其意义  

The clinical meanings of nuclear factor-κB activation in perpherial blood mononuclear cells in patients whith congestive heart failure

作　　者：吕晋琳[1] 杨丽霞[1] 齐峰[1] 王红[1] 王先梅[1] 郭传明[1] 石燕昆[1] 

机构地区：[1]成都军区昆明总医院心内科,昆明650032

出　　处：《临床心血管病杂志》2009年第4期253-255,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨充血性心力衰竭(CHF)患者外周血单个核细胞(PBMCs)的核蛋白提取物——核因子-κB(NF-κB)活性变化的意义及其与心功能的关系。方法:采用ELISA法检测76例心力衰竭患者和30例对照组PBMCs的NF-κB的活性,并与患者心功能及超声心动图参数相比较,研究其与心功能及心肌重塑的关系。结果:CHF患者PBMCs NF-κB活性高于健康对照组,随着心功能恶化和心肌重塑的发展,NF-κB活性逐渐升高(P<0.01)。结论:CHF患者外周血PBMCs中NF-κB活性增高,检测NF-κB活化水平可能有助于心力衰竭恶化的判断。Objective：To investigate the meanings of nuclear factor-κB activation in perpherial blood mononuclear cells in patients with congestive heart failure. Method：The activity of NF-κB on perpherial blood mononuclear cells were measured by ELISA assay in 76 patients with congestive heart failure and 30 healthy subjects. The echocardiographic parameters and cardiac function indexes were also examined and compared with the NF-κB levels. Result：The activities of NF-κB in perpherial blood mononuclear cells were significantly increased in congestive heart failure patients than those in control group, with a negative correlation to the cardiac function indexes and a positive correlation to the heart remodeling indexes （P〈0.05）. Conclusion： The increase of the NF-κB in perpherial blood mononuclear cells may be a predictor of the severity of heart remodeling and heart function failure.

关 键 词：心力衰竭 核因子-ΚB 外周血单个核细胞 

分 类 号：R541.4[医药卫生—心血管疾病]