高血压患者抗AT1受体自身抗体与白细胞介素-4,干扰素-γ的关系探讨  

The study of the relationship between autoantibody against AT1 receptor and interleukin-4 as well as interferon-γ in hypertensive patients

作　　者：陈芬[1] 廖玉华[1] 周子华[1] 陈霄[1] 孙艳香[1] 王敏[1] 郭和平[1] 

机构地区：[1]华中科技大学协和医院心内科华中科技大学同济医学院心血管病研究所,武汉430022

出　　处：《临床心血管病杂志》2009年第4期266-268,共3页Journal of Clinical Cardiology

基　　金：国家自然科学基金资助项目(No:G30300133)

摘　　要：目的:探讨原发性高血压患者抗AT1受体自身抗体与白细胞介素(IL)-4、干扰素(IFN)-γ的关系,以初步了解抗AT1抗体的产生机制。方法:用ELISA方法检测76例原发性高血压患者血清抗AT1抗体、IL-4和IFN-γ的水平,比较抗AT1抗体阳性和阴性组之间IL-4和IFN-γ水平的差异。结果:76例患者中,抗AT1受体抗体阳性和阴性者分别为42和34例,抗体阳性组血清IL-4水平显著高于抗体阴性组[(13.21±0.92)ng/L∶(11.64±0.77)ng/L,P<0.01];而IFN-γ在抗体阳性组与抗体阴性组之间差异无统计学意义[(14.68±2.53)ng/L∶(15.45±1.48)ng/L,P>0.05]。结论:抗AT1受体抗体阳性高血压患者血清IL-4水平高于抗体阴性组患者,Th2细胞功能亢进可能是原发性高血压患者抗AT1受体抗体产生的机制之一。Objective： The present study is to elucidate the mechanism how the autoantibody against AT1 receptor （AT1 AA） is produced, by exploring the relationship between AT1-AA and the cytokines： interleukin-4 （IL-4） and interferon-γ（IFN-γ）. Method： Patients with primary hypertension were recruited and ATR AA,IL-4, IFN-γ were assayed by ELISA. The levels of the IL-4,IFN-γ between the two groups AT1 AA positive and negative groups were compared statistically. Rusult： Out of the 76 subjects, 42 were AT1-AA positive with all the other 34 being negative. Compared to the AT1-AA negative group, the concentration of the IL-4 is higher in the positive group （[13.21±0.92 ]ng/L vs[11. 64±0.77]ng/L; P〈0.05）. There was no statistical difference in the concentration of IFN-γ between the two groups （[14.68 ± 2.53] ng/L; [ 15.45 ± 1.48] ng/L; P〉 0.05 ）. Conclusion： The upregulation of the IL-4 producing Th2 cell function may be one of the mechanisms involved in the production of the AT1 AA.

关 键 词：高血压 AT1受体 自身抗体 白细胞介素-4 干扰素-Γ 

分 类 号：R544.1[医药卫生—心血管疾病]