丙咪嗪抗血小板聚集作用与细胞外Ca_(2+)浓度的关系  

The Relationship between the Platelet Aggregation Inhibited by Imipramine and the Concentration of Extracellular Ca2+

作　　者：付润芳[1,2] 岳京丽[1,2] 贾丹辉[1,2] 可君[1,2] 

机构地区：[1]河南医科大学药理学教研室 [2]河南医科大学附属卫生学校

出　　处：《河南医学研究》1998年第1期19-21,共3页Henan Medical Research

摘　　要：目的：观察丙咪嗪抗血小板聚集作用与细胞外Ｃａ２＋浓度的关系。方法：以比浊度法进行血小板聚集实验。结果：丙咪嗪００１～１ｍｍｏｌ／Ｌ浓度明显对抗凝血酶及二磷酸腺苷诱导的人血小板聚集，且其抗血小板聚集作用随着细胞外Ｃａ２＋增加（加入ＣａＣｌ２１ｍｍｏｌ／Ｌ）与降低（加入乙二醇二乙醚二氨四乙酸１ｍｍｏｌ／Ｌ）而呈现减弱和增强现象，与维拉帕米作用相似。结论：丙咪嗪的抗血小板聚集作用可能与抗钙作用有关。Objective:To study the relationship between the platelet aggregation inhibited by imipramine and the concentration of Ca2+ extracellular.Methods: Platelet aggregation was tested with the method of trubidimetry.Results:It was shown that imipramine (IMI) at a concentration of 0.01～1 mmol/L inhibited significantly human platelet aggregation induced by thrombin and ADP.The inhibition of the platelet aggregation decreased and enhenced according to the increase (adding CaCl2 1mmol/L)and decrease (adding EGTA 1 mmol/L) of the concentration of Ca2+ The effect was similar as Ver. Conclusion: The inhibition of platelet aggregation by IMI may be related to the inhibition of Ca2+

关 键 词：丙咪嗪 血小板聚集 EGTA 凝血酶 氯化钙 

分 类 号：R971.43[医药卫生—药品] R965.2[医药卫生—药学]