长石棉纤维对豚鼠肺泡巨噬细胞的生物学效应  

Experimental Study of Biological Effects of ≥10 μm Asbestos Fiber on Alveolar Macrophages

作　　者：罗陆军[1] 张会斌[1] 谷桂珍[1] 石爱英[1] 王梅 

机构地区：[1]河南省职业病防治研究所

出　　处：《河南医学研究》1998年第1期29-31,共3页Henan Medical Research

摘　　要：目的：探寻长度≥１０μｍ石棉纤维的生物学效应，并且同≤５μｍ石棉纤维的效应作比较。方法：用豚鼠肺泡巨噬细胞体外培育。结果：细胞死亡率和乳酸脱氢酶（ＬＤＨ）活性随培育时间和染尘剂量增加而增加；但钾离子浓度则随时间和剂量的增加而降低。结论：实验结果显示出≥１０μｍ石棉纤维的细胞毒性作用小于≤５μｍ的细胞毒性作用。Objective: Purpose of this experimental study was to survey the biological effects of ≥10 μm asbestos fiber and be compared with the effects of≤5 μm.Methods: Used a experimental method on quineapig alveolar macrophages in vitro.Results: The cytoctosis percent and lactate dehydrogenase increased along with culture time and asbestos fiber increased.But kalium ion (K+),concentration reduced.Couclusion: The experimental results indicated that the cytoxic effcts of ≤5μm asbestos fiber were more intense than ≥10 μm.

关 键 词：石棉纤维 肺泡巨噬细胞 生物学效应 细胞毒性 

分 类 号：R135.2[医药卫生—劳动卫生]