O型孕妇ABO同种异体免疫型IG抗体效价的分析  

Detection of IgG Antibody Titer in Serum of Pregnant Woman with ABO Alloimmunization

作　　者：蒋玉红[1] 宋金莲[1] 张健[1] 刘薇[1] 杨宗军[1] 

机构地区：[1]青岛市妇女儿童医疗保健中心检验科,山东青岛266000

出　　处：《现代生物医学进展》2009年第7期1291-1292,1303,共3页Progress in Modern Biomedicine

摘　　要：目的:检测O型孕妇血清ABO同种异体免疫型IG抗体效价。方法:将1204例O型孕早期孕妇按照其夫的血型分为四组,即O-A、O-B、O-AB-A、O-AB-B,用微柱凝胶法抗人球蛋白试验分别测定抗体效价;同时从中随机选择304例抗体效价≤1:64的孕妇定期检测。结果:在O-A、O-B组中及O-AB组中抗A及抗BIgG抗体效价>64的病例分别占29.88%,19.92%,20.00%及18.18%,各血型组合均有发生新生儿溶血病的可能性,差异无显著性(P>0.05);部分抗体效价低于1:64的孕妇在孕后期效价上升,与孕早期比较差别有统计学意义(t=2.271,P<0.05),且随孕周增大而上升(r=0.979,t=8..293,P<0.05)。结论:常规对孕妇血清血型抗体IgG效价进行检测有助于有助于诊断新生儿溶血病(hemolytic disease of the newborn,HDN),指导临床干预措施,尤其应该注重低抗体效价孕妇的定期检测。Objective：To detect IgG antibody titer in serum of pregnant women with blood type O. Methods：According to the husband＇s blood type, 1204 cases of pregnant women were divided into four groups, that is O-A, O-B, O-AB-A and O-AB-B. IgG antibody titer in serum was detected by anti-human-globulin test in micro-column gel immunoassay. At the same time, 304 cases whose antibody titers ≤ 1：64 were randomly selected to detect regularly. Results：The proportions of IgG antibody titer 〉 64 of pregnant women in O-A blood type couple group, O-B group, O-AB-A and O-AB-B group were 29.88%, 19.92%, 20.00% and 18.18% respectively. The pregnant women in each blood type composition had the same probability of giving birth a neonate with hemolytic disease of the newborn, and the differences were not significant （P 〉 0.05）. Antibody titers increased in the advanced stage for some cases of 304. Comparing with the pregnant women in early pregnancy, the difference is statistically significant （t = 2.271, P〈0.05）. The rate of pregnant women with titer 1：64 increased gradually, when the gestational age increased （r = 0.979, t = 8. 293, P 〈0.05）. Conclusions：Detecting titer of blood type antibody IgG in serum of pregnant women with ABO Alloimmunization is helpful to diagnose hemolytic disease of the newborn and to instruct interventions to lower incidence of the disease.Specially, pregnant women with titer ≤ 1：64 should be paid attention to regularly.

关 键 词：ABO同种异体免疫 IG抗体效价 微柱凝胶法 

分 类 号：R722.18[医药卫生—儿科]