烟碱型乙酰胆碱受体及其神经保护作用  

Nicotinic Acetylcholine Receptors and its Neuroprotective Effects

作　　者：石莎[1] 殷明[1] 

机构地区：[1]上海交通大学药学院神经药理实验室,上海200240

出　　处：《现代生物医学进展》2009年第7期1350-1351,1355,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金(No.30572179)。

摘　　要：新近研究证实,神经元烟碱型乙酰胆碱受体(nAChR)激动后可起到一定的神经保护作用。目前,一些作用于烟碱受体的激动剂已被作为治疗神经退行性疾病如阿尔茨海默病(AD)和帕金森病(PD)的候选药物,但是关于烟碱受体激动后如何发挥神经保护作用及其潜在的分子机制还不清楚,其中有与Ca2+相关的信号转导假说以及神经营养因子等假说。本文就烟碱型乙酰胆碱受体及其神经保护作用的研究进展予以综述。Recently nicotine and other neuronal nicotinic acetylcholine receptor （nAChR） agonists have been used in experimental and clinical trials, and have been found to have neuroprotective effects. Some of them have been considered to be potential eandidates for treatment of neurodegenerative disease such as Alzheimer＇s disease （AD） and Parkinson disease （PD）. Neuroprotective effects have been observed for nAChR activation in vivo and in vitro studies, however, the mechanisms of these effects have not been very clear. This paper reviewed the research on nAChR, neuroprotection ofnAChR activation and molecular mechanisms.

关 键 词：烟碱型乙酰胆碱受体 烟碱受体激动剂 神经保护作用 神经退行性疾病 

分 类 号：Q55[生物学—生物化学] Q593.2