12例急性百草枯中毒患者的救治分析  

Clinical manifestations and treatment of acute poisoning of paraquat： analysis twelve cases

作　　者：贺晓艳[1] 邱俏檬[1] 卢中秋[1] 杜林林[1] 刘刚[1] 李景荣[1] 

机构地区：[1]温州医学院附属第一医院急诊科,浙江325000

出　　处：《中国急救复苏与灾害医学杂志》2009年第4期231-233,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：浙江省教育厅2008年度科研计划项目（Z200803373）

摘　　要：目的 探讨急性百草枯中毒的临床特点及治疗方法。方法回顾分析12例急性百草枯中毒患者的临床资料。其中男7例，女5例，年龄（35±10．5）岁，中毒原因中误服2例，服毒自杀10例。结果百草枯中毒的早期表现为口咽部不适、恶心呕吐、腹痛等，逐渐出现呼吸困难、少尿等各器官受损的表现，予彻底的洗胃、血液灌流及糖皮质激素等治疗，12例患者住院1～28d，3例好转，6例院内死亡，3例自动出院后死亡。结论百草枯有很强的毒性，肺为主要的靶器官，临床上主要表现为急性肺泡炎、急性呼吸窘迫综合征并迅速发展为肺纤维化、多器官功能衰竭等，死亡率高。Objective To investigate the clinical manifestations and therapy of acute paraquat poisoning. Methods The clinical data of 12 patients of acute paraquat poisoning, 7 males and 5 females, aged （35±10.5）, were retrospectively analyzed. Results The reason of poisoning was mistaking in 2 cases and committing suicide in 10 cases. The early clinical manifestations included oral and pharyngeal upset, nausea, vomiting, and abdominal pain. Then multiple organ functional defects, such as dyspnea, oliguria, etc, appeared. Treatment included gastric lavage, hemoperfusion, and glucocorticoid and so on. Three of the 12 patients were cured, six patients died in hospital, and 3 gave up treatment and then died out of hospital. Conclusion Paraquat is highly toxic. The main target organ of paraquat poisoning is the lung. The main pathological changes include acute alveolitis and acute respiratory distress syndrome, and then rapidly progress to pulmonary fibrosis and multiple organ failure. The mortally of paraquat poisoning is high.

关 键 词：百草枯 中毒 血液灌流 

分 类 号：R595.4[医药卫生—内科学]