强心益气汤对压力超负荷大鼠心肌肥大的影响  

Effects of Qiangxin Yiqi Decoction on Myocardium Remodeling of Rats with Pressure Overload

作　　者：张建平[1] 何士彦[2] 吴明华[1] 张伟[1] 李乾[1] 张雪静[1] 楚立[1] 

机构地区：[1]河北医科大学基础课教学部,河北石家庄050091 [2]石家庄市中心医院,河北石家庄050011

出　　处：《辽宁中医杂志》2008年第12期1927-1929,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省科技厅科技攻关课题(06276102D-2906276167);河北省中医药管理局课题(2007023)

摘　　要：目的:探讨强心益气汤对慢性心功能不全大鼠心肌肥大的作用及机制。方法:将SD大鼠48只随机分成4组,实施肾上腹主动脉部分结扎术。假手术组和手术组不予治疗,强心益气汤低剂量组、高剂量组,于术后第4周开始分别给予低剂量(24g生药/kg)、高剂量(72g生药/kg)强心益气汤灌胃,每日1次,连续4周。于术后第8周分别测定各组左室血流动力学变化、左室质量指数(LVMI)、心肌细胞直径(MD)和血浆AngⅡ、ALD、ANP含量。结果:(1)强心益气汤对慢性心功能不全大鼠血浆AngⅡ、ALD、ANP含量的影响:与假手术组相比,模型对照组大鼠血浆AngⅡ、ALD含量升高,ANP含量降低,具有非常显著性差异;与模型对照组相比,各治疗组可见AngⅡ、ALD含量降低,ANP含量升高,具有显著性差异。(2)强心益气汤对慢性心功能不全大鼠心肌肥厚和心肌病理形态学的影响:与假手术组相比,模型对照组左室质量指数、心肌细胞直径均升高,具有显著性差异;光镜下可见心肌细胞肥大,核成方形,间质增生。与模型对照组相比,各治疗组左室质量指数、心肌细胞直径、病理形态学变化都有明显改善,具有显著性差异。结论:强心益气汤可对抗腹主动脉结扎所致心脏重构的影响,阻止和延缓慢性心功能不全的发生发展,部分机制可能与减少机体AngⅡ、ALD和升高ANP机体含量有关。Objective： To observe the effects of Qiangxin Yiqi Decoction （QXYQD） on myocardium remodeling of rats with pressure overload. Methods： Pressure overload rat models were established by partly constricting the abdominal aortas. 48 adult male SD rats were randomly divided into 4 groups, namely ： operation group （ OG）, sham operation group （SOG） , low - dose QXYQD group （ L - QXYQD G, 24g/kg）, high - dose QXYQD group （ H - QXYQD G, 72g/kg）. L - QXYQD G and H - QXYQD G were orally administered with Qiangxin Yiqi Decoction once a day for 4 weeks after operation 4 weeks. The other 2 groups were given the same amount of saline in the same way. The contents of Ang Ⅱ and ALD in plasma, left ventricular weights of the four groups were recorded, and collagen volume fraction （CVF） was determined by videodensitometry at 8th week after operation. Results ： （ 1 ） The effects of QXYQD on contents of Ang Ⅱ and ALD in plasma of rats with pressure overload ： compared with OG group, the Ang Ⅱ and ALD of the SOG group significantly increased; compared with SOG group, those of each treatment group decreased, which had a significant difference. （2） The effects of QXYQD on myocardium remodehng of rats with pressure overload ： compared with OG group, a lot of collagen accompanied of the myofibrilla in the SOG group, the LVMI and CVP of MC group were higher, which had a significant difference ; compared with OG group, those of each treatment group were lower , which had a significant difference. Conclusions ： Qiangxin Yiqi Decoction has beneficial effects on myocardium remodeling, can lighten and postpone the accumulation of myocardial collagen of rats with pressure overload, which may partly depend on decreasing the contents of Ang Ⅱ and ALD in plasma.

关 键 词：强心益气汤 压力超负荷 心功能不全 心肌肥大 

分 类 号：R285.5[医药卫生—中药学]