黄竹清脑口服液对急性脑出血大鼠血清中CRP及脑组织中MDA GSH-PX的影响  

Effect of MDA GSH-PX and CRP in Serum by Huang Zhu Qing Nao Solution(HZQNS) on the Acute Intracerebral Hemorrhage Rat(AICH)

作　　者：刘淑霞[1] 聂伟[1] 杜婴[1] 郭琰[1] 魏光明[1] 

机构地区：[1]陕西中医学院,陕西咸阳712046

出　　处：《辽宁中医杂志》2008年第12期1936-1937,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：陕西省教育厅科研基金项目(03JK089);陕西中医学院科研基金项目(200524)

摘　　要：目的:探讨黄竹清脑口服液对急性脑出血大鼠血清中CRP及脑组织中GSH-PX、MDA的影响。方法:SD大鼠随机分为空白对照组、模型组、尼莫地平组、黄竹清脑口服液大、中、小剂量组。造模成功后开始灌胃给药,日1次,连续7天。然后断头取脑组织及血,测定其中CRP、MDA及GSH-PX含量。结果:(1)ICH大鼠脑内血肿形成后,动物均有神经系统症状;(2)模型组与空白组相比,脑组织中GSH-PX明显降低,MDA明显升高,血清中CRP明显升高,提示造模成功;(3)黄竹清脑口服液大、中剂量组明显优于尼莫地平组和小剂量组。结论:在脑出血急性期,黄竹清脑口服液具有抗氧化、减轻细胞内水肿、抑制炎性反应作用,保护脑神经细胞。To research the effect of MDA,GSH -PX Pase and CRP in serum by Huang Zhu Qing Nao Solution（HZQNS） on acute intracerebral hemorrhage（ICH）. 60 adult male sprapue demey rats were randomly divided into normal contronl group ,ICH model control group,Nimodipine treatment group, HZQNS high -dose treatment group, HZQNS mediate -dose trearment group, HZQNS low - dose trearment group. After ICH model founded successfully, began irrigating medicine into stomach once a day and last 7 days. Then got intracerebral tissue by decollation, measurate MDA, GSH - PX Pase content in the tissuod and CRP in big rat serum. During acute stage of ICH, HZQNS may obviously increase GSH - PX and reduce MDA,CRP Pase activity in brain tissue of rats with ICH. HZQNS is provided with some function such as peroxidation, neurocyte inner dropsy , repress burning to respond an etc. and protect brain neuroeyte.

关 键 词：黄竹清脑口服液 脑出血 谷胱甘肽过氧化物酶 丙二醛 C反应蛋白 

分 类 号：R285.5[医药卫生—中药学]