丹龙醒脑片对局灶性脑缺血再灌注大鼠脑梗死体积的影响  

Effect of Danlong Xingnao Tablet on Volume of Cerebral Infarction in Rats Models of Cerebral Focal Ischemia-reperfusion

作　　者：刘旺华[1] 李花[1] 周小青[1] 何倩[1] 莫莉[1] 张国民[1] 

机构地区：[1]湖南中医药大学基础医学院,湖南长沙410007

出　　处：《辽宁中医杂志》2008年第12期1942-1943,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：湖南省自然科学基金项目(07JJ6056);湖南省教育厅科研项目(07C475)

摘　　要：目的:研究丹龙醒脑片对局灶性脑缺血再灌注后大鼠脑梗死体积和神经功能的影响。方法:用大脑中动脉栓塞1h再灌注47h法建立模型,以图像分析法检测脑梗死体积。结果:局灶性脑缺血再灌注后,模型组脑梗死体积显著增大(P<0.01),神经功能症状计分显著升高(P<0.01);丹龙醒脑大、中剂量片组脑梗死体积较模型组显著缩小(P<0.05),同时,大鼠神经功能症状计分下降(P<0.05)。结论:局灶性脑缺血再灌注后,大鼠脑组织梗死体积增大,丹龙醒脑片能减少脑梗死体积、改善脑缺血后神经症状。Objective： To investigate the effect of the Danlong Xingnao Tablet（DLXNT） on the volume of cerebral infarction and the function of nerves in rats models of cerebral focal ischemia - reperfusion. Methods ： The modle of cerebral focal ischemia - reperfusion was induced by middle cerebral artery occlusion（MCAO） for lh and reperfusion for 47h, technique of image analysis was used to calculate the volume of cerebral infarction. Results ： After cerebral focal ischemia - reperfusion, the volume of cerebral infarction of the modelling group improved significantly （ P 〈 0.01 ）, the symptom scores of the function of nerves increased （ P 〈 0.01 ）. The volume of cerebral infarction and the symptom scores of the function of nerves of highand middle dosed DLXNT group were significantly lower than that of the modelling group＇s （ P 〈 0.05）. Conclusion： After cerebral focal ischemia -reperfusion, the volume of cerebral infarction improved. DLXNT can reduce the volume of cerebral infarction and improve the nervous symptom after cerebral ischemia.

关 键 词：丹龙醒脑片 局灶性脑缺血再灌注 大脑中动脉 脑梗死 

分 类 号：R285.5[医药卫生—中药学]