神昌注射液对脑栓塞大鼠ET CGRP及血脑通透性的影响  

Effects of Shenchang Injection on ET CGRP and BBB in MCAO Rats

作　　者：方永奇[1] 李翎[1] 林双峰[1] 李小兵[1] 王丽新[1] 

机构地区：[1]广州中医药大学第一附属医院实验中心,广东广州510405

出　　处：《中华中医药学刊》2008年第12期2542-2543,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：广东省科技厅攻关课题(2003C34403)

摘　　要：目的:探讨神昌注射液对缺血再灌注脑损伤大鼠内皮素、降钙素基因相关肽及血脑通透性的影响。方法:MCAO法造成大鼠脑缺血再灌注损伤模型,静脉给药7次,采用放射免疫法测定血浆内皮素、降钙素基因相关肽含量,并测定血脑通透性。结果:神昌注射液能明显降低血浆内皮素含量,升高降钙素基因相关肽含量,对血脑通透性则无明显影响。结论:神昌注射液有舒张脑血管,改善脑供血的作用,但对血脑通透性影响不大。Objective：To observe effect of Shenchang injection on ET、CGRP and blood brain barrier（BBB） in MCAO rats.Methods：The ischemia/reperfusion cerebral injury model was made in rat by MCAO.Shenchang injection was given by iv for 7 days,then ET,CGRP and BBB were observed.Results：Shenchang injection could decrease ET but increase CGRP in MCAO rats.No marked effect of BBB were observed after treatment.Conclusion：Shenchang injection is effect to improve blood supply of brain.

关 键 词：神昌注射液 石菖蒲 冰片 内皮素 降钙素基因相关肽 

分 类 号：R284.1[医药卫生—中药学]