银杏叶聚戊烯醇对移植性肉瘤的治疗作用  

Theraputical Effects of Folium Ginkgo Polyprenols on Transrlanting Sarcoma

作　　者：高凌[1] 钱新华[1] 亢寿海[1] 张能芳[1] 张琴芬[1] 

机构地区：[1]江苏省肿瘤防治研究所,江苏南京210009

出　　处：《中华中医药学刊》2008年第12期2618-2620,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省科技厅社会发展项目(BS2001065)

摘　　要：采用抗移植性肿瘤实验方法研究银杏叶(Folium Ginkgo)的活性物质—聚戊烯醇(Polyprenols GP-1)对肉瘤S180的治疗作用。结果表明,GP-1以20.0 mg/kg连续给药8天对S180的抑制率为47.35%,连续给药15天对S180抑制率可达62.57%;GP-1分别与化疗药物CTX,PDD及5-Fu联合,对治疗S180有良好的协同作用;低剂量GP-1可增强S180荷瘤小鼠对60Co放射治疗的敏感性。GP-1对S180有良好的抗种瘤作用。Objective：To study the therapeutical effects of polyprenols（GP-1）extracted from Folium Ginkgo on sarcoma model（S180）.Methods：Using grafting tumor models in mice.Results： The inhibitory rate were 24.78%,37.61%and 47.35%（P〈0.05）respectively when GP-1 was given orally at the dose of 5.0mg/kg,10.0mg/kg and 20mg/kg on eight successive day;and the inhibitory rate were 46.20%,47.95%,59.06%and 62.57%at the dose of 2.5mg/kg,5.0mg/kg,10.0mg/kg and 20mg/kg on fifteen successive day（P〈0.001）.Combined with CTX,PDD and 5-Fu respectively,GP-1 had synergic effects of antitumor on S180;GP-1 at low dose can improve the sensitivity of mice born S180 to radiotherapy of 60Co.Conclusion：GP-1 had significant antitumor effects on S180.

关 键 词：银杏叶聚戊烯醇 抗肿瘤 S180 

分 类 号：R285.5[医药卫生—中药学]