T型分叉血管中血液流动对动脉血栓形成的影响  

Influence on thrombus formation by blood flow in T-bifurcation of artery

作　　者：马瑞艳[1] 刘赵淼[1] 张谭[1] 叶红玲[1] 史艺[2] 

机构地区：[1]北京工业大学机械工程与应用电子技术学院,北京100124 [2]中国医学科学院阜外心血管医院,北京100037

出　　处：《医用生物力学》2009年第2期98-106,共9页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(10502002);北京市人事局留学回国人员择优资助项目;教育部留学基金资助项目

摘　　要：目的从血流速度、分支直径、T型分叉角度及血液黏度的血流动力学角度,并结合相关医学病例,研究T型分叉血管中血液流动对血栓形成的影响,从多学科角度分析并验证医学研究中的有关血栓形成机理的猜测。方法建立T-型动脉血管的几何模型,采用计算流体动力学方法对血管内流场进行数值分析研究,分析不同条件的流动对血栓形成影响。结果在分叉血管附近的支血管和主血管中分别形成了两处较大区域的涡流区域,另外,在分叉交接处的下游位置也出现了一处较小的区域,这些区域速度较低,剪应力出现突然增大趋势,符合血栓形成,因此成为"最适成栓位置"。结论血栓在"最适成栓位置"的形成还与分支血管直径、血管中血流速度、分叉角度以及血液黏度等有密切关系。Objective To analyze the influence on thrombus formation by the changes of blood flow in T-bifurcation vessel from hydrodynamics perspectives, mainly considering blood velocities, branch vessel diameters, T-bifurcation angles and blood viscosities. Combined with pertinent medical cases, the hypothesis about thrombus formation here is studied and validated from all multidisciplinary angles. Method The geometry model of T-bifurcation artery is created to numerically analyze the flow field in vessel and the influence of different kinds of blood flow on thrombus formation. Result There appeared two ＂larger-regional＂ vortexes in the main and branch vessel near bifurcation. In addition, downstream the bifurcation joint, also appeared a smaller region, where local velocity is lower and shearing stress appears to abruptly increase, which is in favor of throm bus and could be ＂location apt to thrombus＂. Conclusions Throm bus formation in ＂location apt to thrombus＂ is also closely related with branch vessel diameter, blood velocity, bifurcation angle and blood viscosity.

关 键 词：T型分叉 动脉血栓 壁面剪应力 壁面压强 

分 类 号：V035[航空宇航科学技术]