凝血因子和血小板参数检测在各种肝病中的临床意义  

Coagulation the factor and platelet parameters in a variety of detection of liver disease in the clinical significance

作　　者：宋燕[1] 于景云[1] 王璐[1] 

机构地区：[1]大连大学附属新华医院检验科,辽宁大连116021

出　　处：《中国医疗前沿（学术版）》2008年第12期8-9,共2页China Healthcare Innovation

摘　　要：目的探索凝血因子和血小板参数指标的变化在各型病毒性肝炎患者病情变化中的临床意义。方法对286例(男224,女62)肝病患者及32例健康对照组进行凝血酶原时间{PT}、活化部分凝血活酶时间(APTT)、纤维蛋白原{FBG}、和血小板计数{PLT}、血小板压积{PCT}、血小板平均体积(MPV)、血小板分布宽度{PDW}指标检测。结果PT、APTT、FBG、TT、PLT、PCT、MPV、PDW8项指标中,急慢性肝炎的TT、APTT、PT活性和纤维蛋白原含量基本在正常范围内,唯慢性肝炎PT活性有轻度下降,与对照组比较,差异显著(p<0.05);肝硬化和重症肝炎APTT、PT、TT活性降低、FBG含量明显减少,与对照组比较差异非常显著{p<0.01}。PLT、PCT明显减少,与对照组比较,差异非常显著(p<0.01)。血小板分布宽度(PDW)均值增大,且血小板分布曲线呈"平台"或"小抛物线"型改变。结论凝血因子、血小板参数的检测对于肝硬化、重型肝炎患者肝脏损害程度、病情观察、预后判断有重要的临床意义。Objective Exploration Platelet parameters of the change in the indicators of various types of viral hepatitis patients in the clinical significance of the changes. Methods For the 286 cases （224 men, 62 women） Patients with liver disease and 32 healthy control groupFor prothrombin time （PT）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）, and platelet count （PLT）, platelet hematocrit （PCT）, mean platelet volume （MPV）, platelet release＇width （PDW） targets detection.Result PT, APTT, FIB, TT, PLT, PCT, MPV, PDW8 indicatorAcute and chronic hepatitis TT, APTT, PT and the activity of fibrinogen content in the normal range of Only chronic active hepatitis PT slight decline. Compared with the control group, significant differences （p 〈0.05） Severe hepatitis and cirrhosis APTT, PT, TT activity, FBG were significantly reduced, compared with the control group the difference was significant （p 〈0.01） PLT, PCT decreased compared with the control group, the difference was significant （p 〈0.01）Platelet distribution width （PDW） average increase, and platelet distribution curve ＂platform＂ or ＂small parabolic＂ type change. Conclusion Coagulation factor and platelet parameters for the detection of liver cirrhosis, liver damage in patients with severe hepatitis, disease observation and prognosis have important clinical significance.

关 键 词：凝血因子 肝硬化 重症肝炎 血小板 

分 类 号：R446.11[医药卫生—诊断学] R575[医药卫生—临床医学]