大气可吸入颗粒物造成肺损伤的NF-κB研究进展  

Progress of study on the NF-κB signaling pathway in the lung injury induced by inhalable particle

作　　者：彭辉[1] 周绮云[1] 刘璇[1] 赵晓红[1] 

机构地区：[1]北京联合大学应用文理学院,北京100083

出　　处：《生命科学》2009年第2期259-263,共5页Chinese Bulletin of Life Sciences

基　　金：北京市自然科学基金项目(7092015);北京市中青年骨干教师资助项目

摘　　要：NF-κB信号通路在大气可吸入颗粒物(PM10)对肺的损伤过程中起到重要的作用,但NF-κB信号通路参与的损伤机理尚不清楚。本文对NF-κB的结构与组成、颗粒物中NF-κB的激活因素、激活过程和抑制剂的相关研究等内容做简要综述。Many epidemiologic studies have shown that the NF-κB signaling pathway plays an important role in the lung injury by induction of inhaled particle matter. However, the exact toxicological damage mechanisms which the NF-κB signaling pathway takes part in are still unresolved. This paper described the progress of study on the NF-κB signaling pathway in the lung injury induced by inhaled particle matter home and abroad. In this article, the component of NF-κB, the activate factor of NF-κB in particle matter, the activation process and the inhibitor were reviewed.

关 键 词：大气可吸入颗粒物 NF-ΚB信号通路 NF-κB通路抑制剂 

分 类 号：X513[环境科学与工程—环境工程] X503.1