甲壳质对氧自由基致人脐静脉内皮细胞损伤的保护作用  

PROTECTIVE EFFECT OF CHITIN ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVECs) INJURED BY OXYGEN FREE RADICALS IN VITRO

作　　者：陈同坡[1] 宋晓梅[1] 李志平[1] 闫美兴[1] 张立华[1] 

机构地区：[1]青岛市立医院药剂科,青岛266011

出　　处：《中国海洋药物》1998年第1期28-30,共3页Chinese Journal of Marine Drugs

摘　　要：在培养的人脐静脉内皮细胞中观察了不同剂量的甲壳质对氧自由基损伤的内皮细胞培养上清液中丙二醛和乳酸脱氢酶含量的影响。结果表明,与损伤对照组相比,甲壳质保护组培养上清液中丙二醛和乳酸脱氢酶的含量均显著下降。提示甲壳质对氧自由基损伤的内皮细胞有一定的保护作用。The effect of chitin on human umbilical vein endothelial cells (HUVECs) injured by oxygen free radicals was investigated in vitro. The degree of injury was determined by the amount of malondialdehyde (MDA) and lactic dehydrogenase (LDH) in the culture medium. The results indicated that chitin could reduce the amount of MDA and LDH significantly, showing that chitin could protect HUVECs from oxygen free radicals injury.

关 键 词：甲壳质 丙二醛 动脉粥样硬化 氧自由基 

分 类 号：R543.505[医药卫生—心血管疾病] O636.11[医药卫生—内科学]