Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation （HGAP） Method  

作　　者：赵宏 王洁欣 张海霞 沈志刚 甄崇礼 陈建峰 

机构地区：[1]Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 10029, China [2]Nanomaterials Technology Pte. Ltd., Singapore

出　　处：《Chinese Journal of Chemical Engineering》2009年第2期318-323,共6页中国化学工程学报（英文版）

基　　金：Supported by the National High Technology Research and Development Program of China (2006AA030202);the Talent Training Program of Beijing (2007B022)

摘　　要：The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation （HGAP） process. Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment （rotating packed bed） in carrying out the anti-solvent precipitation process to produce nanoparticles. The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles. The Brunauer-Emmett-Teller （BET） surface area sharply increases from 0.66 m^2·g^-1 to 15.08 m^2·g^-l. Accordingly, the dissolution rate is greatly improved. The molecular state, chemical composition, and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared （FTIR） and X-ray diffraction （XRD）, The high recovery ratio and continuous production capacity are highly appreciated in industry. Therefore, the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m2·g-1 to 15.08 m2·g-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical composition,and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

关 键 词：high-gravity antisolvent precipitation  rotating packed bed danazol  nanoparticles  dissolution rate 

分 类 号：TQ564.06[化学工程—炸药化工] TS210.1[轻工技术与工程—粮食、油脂及植物蛋白工程]