孕妇血清表皮生长因子在判断胎儿成熟度中的价值  

Assessment of Fetal Maturation by Epithelial Growth Factor in Serum of Pregnant Women

作　　者：王丹瑞[1] 曹树军[1] 崔礼敬[1] 杜兴邦[1] 周国宏 赵昌银[1] 宋鑫[1] 李艳[1] 

机构地区：[1]湖北省十堰市太和医院妇产科

出　　处：《中华妇产科杂志》1998年第3期150-152,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的了解正常孕妇在妊娠各期血清中表皮生长因子（ＥＧＦ）及孕激素（Ｐ），与羊水中ＥＧＦ、Ｐ、淀粉酶（Ａｍｓ）、肌酐（Ｃｒ）、间接胆红素（ＴＢ）的浓度变化在判断胎儿成熟度中的价值。方法用放射免疫法测定正常孕妇１８１例（早孕３５例，中孕６９例，晚孕７７例）血清及其中８７例孕妇（中孕４４例，晚孕４３例）羊水中的ＥＧＦ、Ｐ浓度变化；用生化分析仪测定此８７例孕妇羊水中Ａｍｓ、Ｃｒ、ＴＢ浓度变化。同时还对其中２３例足月分娩的新生儿的脐静脉、脐动脉血清中ＥＧＦ及Ｐ的浓度进行测定。结果孕妇血清中ＥＧＦ和Ｐ的浓度均随孕周增长而增加。羊水中ＥＧＦ浓度与羊水中Ａｍｓ、Ｃｒ浓度呈正相关。孕３２周以后，当ＥＧＦ≥４．５μｇ／Ｌ时，胎儿成熟率为７０．５９％。Objective To study the concentrations of human epithelial growth factor (EGF), progesterone (P) in serum, and EGF, P, amylase (Ams), creatinine (Cr) and total bilirubin (TB) in amniotic fluid at different trimester normal pregnancy. Methods The concentrations of EGF, P in serum of 181 cases of pregnant women (first trimester 35, midtrimester 69, late trimester 77) and the concentrations of EGF, P, Ams, Cr, TB in amniotic fluid of 87 cases (mid trimester 44, late trimester 43) were determined. At the same time, the concentrations of EGF, P in serum of umbilical veins and arteries from 23 full term neonates were determined as well. The concentrations of EGF and P were measured by radioimmunoassay and Ams, Cr, TB in amniotic fluid by PA110 autobiochemistry analyzer. Results (1) The concentrations of EGF, P in serum increased as pregnancy advanced. (2) There were significant correlations between EGF level and Ams, Cr levels in amniotic fluid. After 32 gestational weeks, the fetal maturity rate was 70.59% when EGF was ≥4.5 μg/L. There were significant positive correlations between EGF in maternal serum and in amniotic fluid. (3) The maternal serum EGF concentration was significantly higher than that in the umbilical vessels, and there was positive correlations between them. Conclusion The change of maternal serum concentration could be used to determine the fetal maturation.

关 键 词：表皮生长因子 孕激素 胎儿 器官成熟度 

分 类 号：R714.51[医药卫生—妇产科学]