42例散发戊型肝炎临床与病原学观察  

Clinical and serological analysis of scattered hepatitis E

作　　者：武菲菲[1] 王金花[1] 陈志娇[1] 王菊英[1] 希向红 

机构地区：[1]宁夏医学院附属医院传染科

出　　处：《宁夏医学杂志》1998年第2期80-81,共2页Ningxia Medical Journal

摘　　要：目的进一步观察戊型肝炎临床与病原学。方法对１００４例住院的各型病毒性肝炎，用ＥＩＡ法检测甲～戊五型病毒性肝炎血清标志。结果检出抗ＨＥＶ阳性４２例，检出率为４．１８％。低于同期ＨＢＶ和ＨＡＶ感染，居ＨＡＶ～ＨＥＶ五型感染的第三位。并对４２例ＨＥＶ感染者进行了临床及病原学观察，显示以男性青壮年多见。ＨＥＶ与ＨＢＶ、ＨＡＶ双重感染高于单纯ＨＥＶ感染（Ｐ＜０．０５），其中以ＨＢＶ与ＨＥＶ双重感染最多见，占ＨＥＶ感染的７１．４２％。乙肝肝硬变重叠ＨＥＶ感染易出现病情加重，恢复迁延，预后欠佳。结论ＨＡＶ与ＨＥＶ双重感染比单纯ＨＥＶ感染发病年龄下移（Ｐ＜０．０５），但病情无加重。戊型重型肝炎发病率较高。ＨＥＶ多重感染，临床恢复迁延。bjective In order to observe clinic and serological of Hepitatis E Virus. Methods Serum Marker of the patients with of Hipitatis Virus in patient was tested by the method of EIA.Anti-HEV was tested in 1004 patients with varied viral hepatitis.There were 42 cases whose Anti-HEV were positive. Results The positive rate was 4.18% which was lower than that of HBV and HAV within same peariod.HEV infection was more often in young and middle aged people.HEV/HBV and HEV/HAV superinfection were more often as compared with HEV infection alone(P<0.01).HEV/HBV superinfection was the greater part of the 42 cases (71.42%).HEV superinfection in hepatitis B cirrhosis would result in the worsening of the hepatopathy,prolongation of the course of disease and doubtful prognosis. Conclusion The age of HEV/HAV superinfection was decreased when compared with that of HEV infection alone (P<0.05).The attack rate of fulminant E hepatitis was high.HEV multiinfection can prolong the course of disease.

关 键 词：戊型肝炎 散发性 病原学 

分 类 号：R512.630.2[医药卫生—内科学]