女性系统性红斑狼疮合并肺动脉高压患者的西地那非联合辛伐他汀治疗  

Treatment of Sfldenafil combined with Simvastatin on pulmonary hypertension in female SLE patients

作　　者：林玲[1] 壮可[1] 寿涛[2] 乌若丹[1] 彭晓燕[2] 赵燕[1] 张宏[1] 

机构地区：[1]云南省第一人民医院心内科,650032 [2]云南省第一人民医院风湿免疫科

出　　处：《中国临床实用医学》2009年第4期83-84,共2页China Clinical Practical Medicine

摘　　要：目的 探讨女性系统性红斑狼疮合并肺动脉高压患者的西地那非联合辛伐他汀治疗的疗效。方法26名女性系统性红斑狼疮合并肺动脉高压患者分为单药治疗组和联合治疗组各13例。前者急性血管反应性试验阳性者11例，阴性者2例，11例予氨氯地平片2．5mg1次／d，一周后加量至5mg1次／d。2例予雷米普剂片2．5mg，1次／d，1周后加量至5mg，1次／d。后者予西地那非片50mg，3次／d及辛伐地汀80mg，1次／d，两组疗程均为3个月。试验前后进行生活质量问卷评分（QOL），并测量右室收缩压，（RVSP）及6min步行距离（6-MWT）。结果两组患者治疗后QOL，RVSP及6-MWT均较治疗前有明显改善，与单药治疗组相比，联合治疗组各指标改善更为显著。结论西地那非联合辛伐他汀治疗女性系统性红斑狼疮和并肺动脉高压患者疗效较好。比单药治疗组能更有效地降低肺动脉压，改善生活质量，提高运动耐力。Objective Investigate the clinic efficacy of combination use of Sildenafil and Simvastatin on pulmonary hypertension in female patients with SLE. Methods 26 female SLE patients with PH were randomly divided into solo-medication group （ n = 13 ） and combined-medication group （ n = 13 ）. In the former group, there are 11 patients positive in acute artery reaction test and 2 negative, 11 positive patients received Amlodipine 2. 5 mg qd, then 5 mg qd a week later; 2 negative patients received Ramipril 2. 5 mg qd, then 5 mg qd a week later. The latter group received Sildenafil 50 mg rid and Simvastatin 80 mg qd. The treatment duration is 3 months. The change of Quality of Life（QOL） ,RVSP,6-MWT were measured after drugs were given. Results QOL,RVSP and 6-MWT were all effectively improved in both groups after treatment. Compared with solomedication group,the change of QOL,RVSP and 6-MWT was much more significantly. Conclusion Combination use of Sildenafil and Simvastatin could alleviate PH, improved quality of life and exercise tolerance more effectively compared with traditional treatment.

关 键 词：系统性红斑狼疮 肺动脉高压 西地那非 辛伐他汀 

分 类 号：R593[医药卫生—内科学] R544[医药卫生—临床医学]