血栓调节蛋白及细胞间粘附因子检测在急性冠脉综合征中的临床应用  

The clinical application of sTM and sICAM-1 in the patients with acute coronary syndromes

作　　者：江雁[1] 穆红[1] 唐志琴[1] 

机构地区：[1]天津市第一中心医院,天津300192

出　　处：《哈尔滨医药》2009年第2期1-1,3,共2页Harbin Medical Journal

摘　　要：目的探讨可溶性血栓调节蛋白、可溶性细胞间粘附因子-1水平在急性冠脉综合征发病中的作用。方法分别对40例不稳定心绞痛、40例急性心肌梗死患者及40例健康对照采用ELISA法测定血清中可溶性血栓调节蛋白、可溶性细胞间粘附因子-1。结果UAP组、AMI组及ACS组sTM水平明显高于对照组;其中AMI组sTM水平与UAP组相比无统计学差异;AMI组、ACS组sICAM-1水平高于对照组,AMI组sICAM-1水平高于UAP组。结论sTM、sICAM-1水平是反映ACS患者内皮细胞损伤程度和范围的良好标志。Objective To investigate the application of sTM and sICAM - 1 in the patients with ACS. Methods sTM and sICAM - 1 were detected by ELISA in 40 patients with UAP,40 patients with AMI and 40 health indi- vidals. Results The sTM levels of UAP,AMI and ACS were higher than health control. There was no differents be- teen UAP patients and AMI patients in the sTM level. The sICAM - l levels of AMI and ACS were higher than health control. And the sICAM - 1 level of AMI was higher than UAP. Conclusion sTM and slCAM - 1 are good markers which can reflect the damage of endothelial cells.

关 键 词：急性冠脉综合征 血栓调节蛋白 细胞间粘附因子 

分 类 号：R446[医药卫生—诊断学]