神经肌肉电刺激诱发健康年轻人手部运动时脑功能性磁共振成像研究  

Investigation of functional magnetic resonance imaging of brain during hand movement induced by neuromuscular electrical stimulation of healthy young subjects

作　　者：靳晓坤[1,3] 燕铁斌[1] 郑芳芳[1] 段小慧[2] 沈君[2] Hui-Chan CWY 

机构地区：[1]中山大学附属第二医院康复医学科,广州510120 [2]中山大学附属第二医院放射科,广州510120 [3]广州市儿童医院神经康复科 [4]香港理工大学康复科学系

出　　处：《中华物理医学与康复杂志》2009年第4期249-252,共4页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：香港理工大学重点学科发展基金（1.104.A106）

摘　　要：目的观察神经肌肉电刺激（NMES）诱发健康年轻人手部运动时的脑功能性磁共振成像（fM-R1），探讨NMES对中枢神经系统的影响。方法6位健康志愿者参与本项研究，其中男5例，女1例，年龄（25．17±3．43）岁，在NMES的作用下引出手部腕背伸和拇外展动作，刺激电流的参数为：频率30Hz，脉宽0．2ms，双向方波，通电：断电=2s：2s，波升：波降=1：1，电流强度以受试者可耐受的最大强度为准。通过fMRI技术获得脑功能变化图像，利用统计参数图2（SPM2）软件进行图像分析，得出激活脑区的定位信息。结果NMES诱发健康人的手部运动时，主要激活对侧及同侧运动皮质和躯体感觉皮质。结论健康人NMES诱发手部运动可以引起大脑运动皮质及躯体感觉皮质的兴奋性改变反应。Objective To observe fMRI images of brain during hand movement induced by NMES of healthy young subjects and to explore the possible mechanism of NMES to central nervous system. Methods Six right-handed healthy volunteers including 5 males and 1 female, aged 25.17 ± 3.43 years underwent fMRI scanning while NMES was applied to right wrist extensors to elicit a maximal wrist extension. The parameters of stimulation electric current were： frequency 30 Hz, pulse width 0.2 ms, biphase square wave, on time：off time =2 s：2 s, ramp 1 and the intensity was maximal tolerance by subjects. Functional images were processed using SPM2 software package to obtain the localized information in activated cortex region. Results All of the 6 subjects showed fMRI responses upon NMES. Most of wrist extensor stimulated by NMES was associated with activation of the primary motor cortex （ M1 ） , pre-motor cortex （PMC）, supplementary motor cortex （SMC）, primary somatosensory cortex （SI）. The functional responses arise not only in contralateral cortex, but also in ipsilateral cortex to the stimulated hand movement. Conclusion Wrist extention elicited by NMES can evoke fMRI responses in motor cortex and somatosensory cortex in healthy subjects.

关 键 词：神经肌肉电刺激 功能性磁共振成像 运动皮质 躯体感觉皮质 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]