股骨头坏死病因与发病机制研究进展  

Etiology and pathogenesis of osteonecrosis of the femoral head

作　　者：赵海燕[1] 夏亚一[1] 康鹏德[2] 

机构地区：[1]兰州大学第二医院骨科研究所,兰州730030 [2]四川大学华西医院骨科,四川610041

出　　处：《中国矫形外科杂志》2009年第8期604-607,共4页Orthopedic Journal of China

基　　金：国家自然科学基金资助项目(编号:30772202)

摘　　要：股骨头缺血坏死(osteonecrosis of the femoral head,ONFH)是由不同病因导致股骨头血液供应中断及缺氧而引起髋关节退行性骨性关节炎,继而造成股骨头塌陷,其病理生理学机制尚未完全明了。目前认为激素和酒精的摄入是股骨头缺血坏死最常见的两大病因。目前对其发病机制提出的学说主要有:脂类代谢紊乱学说、骨内高压学说、血管内凝血学说、二次碰撞学说等。本文就股骨头缺血坏死病因及发病机制研究进展做一综述。Disruption of blood supply to the femoral head and subsequent hypoxia are implicated in the pathogcnesis of osteonecrosis of the femoral head （ ONFH）, which frequently leads to the progressive collapse of the femoral head, thus causing degenerative arthritis of the hip joint. But the pathophysiology of osteonecrosis of the femoral head has not been completely elucidated. It is accepted that steroids and alcohol intake are two most common causes of ONFH. Now many theories have been proposed to decipher the etiology and pathogenesis of ONFH,including abnormal lipid metabolism,elevated intraosseous pressure, intravascular coagulation, second collision theory,etc. The purpose of this review is to summarize the etiology and pathogenesis of osteonecrosis of the femoral head.

关 键 词：股骨头缺血坏死 病因 发病机制 

分 类 号：R681.8[医药卫生—骨科学]