急性吗啡染毒大鼠体内吗啡的定位研究  

Distribution of Morphine in Acute Morphinetreated Rats

作　　者：徐振波 汪秉康 王文东 

出　　处：《华西医科大学学报》1998年第1期29-32,共4页Journal of West China University of Medical Sciences

摘　　要：用免疫组织化学法对经腹腔注射吗啡大鼠体内吗啡的分布进行定位观察。结果表明，吗啡分布在心脏、肝脏、脾脏、肾脏、肾上腺、胃、小肠、胰岛、颌下腺和舌下腺中，腹腔注射吗啡１０分钟后，吗啡即在心脏、肝脏、脾脏、胰岛、小肠粘膜中出现；１６０分钟后，心脏和胃可观察到吗啡存在。该研究提供了给药后不同时间吗啡在体内的分布情况，可为吸毒致死后尸检取材提供参考依据。The distribution of morphine in acute morphinetreated rats was studied by immunohistochemistry(PAP). Samples were examined for morphine distribution and localization in internal organs at 10160 min after intraperitoneal injection of morphine. The results showed that morphine was distributed in the heart, hepatocytes, epithelial cells of the bile canalicular cells in liver, spleen, kidney, adrenal glands, stomach parietal cells, small intestinal villus, pancreas islet, sublingual glands and submandibular glands. Morphine was found in the cardiac tissue, liver, spleen, pancreas islet, small intestinal villus at 10 min after injection and in the cardiac tissue, stomach parietal cells at 160 min after injection. The cause of the postmortem the distribution of morphine in internal organs at different times after injection was discussed. The results of this study may be used as a basis for the choice of samples for the forensic toxicological analysis.

关 键 词：吗啡 组织分布 免疫组织化学 麻醉剂中毒 

分 类 号：R595.5[医药卫生—内科学]