比较布比卡因两种pH值对病人的药效和药物动力学的影响  

The influence of bupivacaine solution of two different pH on pharmacodymamics and pharmacokinetics

作　　者：高振强[1] 赵秋生[1] 刘志双[1] 李玉环[1] 刘珠[2] 梅华[2] 

机构地区：[1]河北医科大学第三医院 [2]石家庄市药品检验所

出　　处：《中国医院药学杂志》1998年第2期51-53,共3页Chinese Journal of Hospital Pharmacy

摘　　要：考察了臂丛麻醉时提高布比卡因溶液ｐＨ值对麻醉起效时间、止痛维持时间及布比卡因药物动力学的影响。１６名成年病人被随机分成两组。Ａ组（ｎ＝８）用０．７５％布比卡因溶液（ｐＨ５．５０）麻醉，Ｂ组（ｎ＝８）用０．７５％布比卡因溶液（ｐＨ６．４）麻醉。结果显示提高布比卡因溶液的ｐＨ可明显缩短麻醉起效时间，Ａ、Ｂ两组分别为４．７５ｍｉｎ和２．３１ｍｉｎ（Ｐ＜０．０５），延长止痛维持时间：Ａ、Ｂ两组分别为９．５８ｈ和１８．１０ｈ（Ｐ＜０．０５），而两组的药物动力学参数差异无显著性（Ｐ＞０．０５）。The paper investigates the influence of increasing the pH of the bupivacaine solution for brachial plexus anesthesia oon time of onset of local anesthesia and the duration of useful analgesia. Sixteen adult patients were randomly allocated into one of two groups.Group A(n=8) received brachial plexus anesthesia with 0.75% bupivacaine solution(pH5.50)while Group B(n=8) received 0.75% bupivacaine solution(pH6.47),Raising the pH of bupivacaine solution significantly reduced time of onset of local anesthesia from 4.75 minutes in Group A to 2.31 minutes in Group B(p<0.05)and prolonged the duration of useful analgesia from 9.58 hours in Group A to 18.10 hours in Group B(P<0.05)。There was no significant difference in pharmacokinetic parameters between the two groups(P>0.05).

关 键 词：布比卡因 药效学 药物动力学 PH值 

分 类 号：R971.2[医药卫生—药品] R969[医药卫生—药学]