抗坏血酸有机锗倍半氧化物抑制鸡胚尿囊膜血管生成作用的研究  

Antiangiogenesis Effect of Ascorbic Acid SesquioxyGe(Ⅳ) on Chicken Embryo Chorioallantoic Membrane

作　　者：陈芳[1] 闫静[1] 郭冷秋[1] 贾桂芝[1] 张基庆[1] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《时珍国医国药》2009年第4期897-899,共3页Lishizhen Medicine and Materia Medica Research

基　　金：黑龙江省自然科学基金(No.2004-04)

摘　　要：目的研究抗坏血酸有机锗倍半氧化物对鸡胚尿囊膜(CAM)血管生成的抑制作用。方法在七日龄CAM上植入含不同剂量试药的甲基纤维素膜片,并孵化48 h。解剖显微镜下计数加药组和对照组局部血管数,以此来反映试药对CAM新生血管形成的影响。结果抗坏血酸有机锗倍半氧化物2.5,1.5,0.5 mg/egg剂量相关性减少CAM局部的血管数。结论抗坏血酸有机锗倍半氧化物对CAM新生血管有显著的抑制作用。Objective To investigate the antiangiogenesis effect of the ascorbic Acid SesquioxyGe（Ⅳ） on chicken embryo chorioallantoic membrane （CAM）. Methods The ascorbic acid SesquioxyGe （Ⅳ ） loaded with methylcellulose membranes was applied on chicken CAM surface of 7 - day - old eggs and incubated for 48 hours . Local vessel density was measured under dissection microscope . The inhibitory effect on CAM angiogenesis was evaluated. Results The Ge（Ⅳ ） complex with ascorbic acid at 2.5,1. 5 rag/egg and 0.5 mg/egg dose - dependently decreased the density of local blood vessels. Conclusion Ascorbic acid Sesquioxy- Ge（ Ⅳ ） significantly inhibits chicken CAM angiogenesis .

关 键 词：抗坏血酸有机锗倍半氧化物 鸡胚尿囊膜(CAM) 抗血管生成 

分 类 号：R285.5[医药卫生—中药学]