辣椒碱微乳的皮肤刺激性研究  

Experimental study on skin irritation of capsaicin microemulsion

作　　者：段晓彦[1] 何瑞波[2] 张鹏威[3] 魏焕萍[2] 吕少文[4] 张莉[3] 

机构地区：[1]武警医学院科研部成果处,天津300162 [2]武警医学院病理学教研室,天津300162 [3]武警医学院药剂学教研室,天津300162 [4]武警医学院组织胚胎学教研室,天津300162

出　　处：《武警医学院学报》2009年第2期88-89,132,F0004,共4页Acta Academiae Medicinae CPAPF

基　　金：武警医学院院级科研基金项目(WY2006-15)

摘　　要：【目的】评价辣椒碱微乳的皮肤刺激性。【方法】通过人体志愿者单次给药和小鼠多次给药相结合,用人体主观感受和皮肤色度分析作为单次给药评价指标,用皮肤组织切片观察多次给药的皮肤刺激反应。【结果】辣椒碱微乳的单次给药发生瘙痒、发热感、刺痛和疼痛的时间分别为7.3,17.3,11.4和15.2 min,均比乳膏相应的反映时间短(P<0.01),色度C*和多红斑指数ΔE*也比软膏相应的指标大。小鼠皮肤组织切片无明显病理学改变。【结论】辣椒碱微乳的刺激性较小,是一具有开发潜力的新型透皮给药系统。[Objective] To evaluate the skin stimulation of capsaicin microemulsion. [Methods] Single-dose on human volunteers and muhidoses on mice were carried out in combination. The subjective feelings coupled with color analysis were used as single - dose evaluation index. Histological examination was used as multidoses evaluation index. [ Results] The onset time in singledose of itching, heating, stinging aud pain was 7.3, 17.3, 11.4 and 15.2 minutes, respectively, which was shorter than that of ointment （P 〈 0.01 ） . The chroma and multiple erythema index were higher that that of ointment. Histological studies showed no undue reactions of the skin. [ Conclusions] The stimulus of capsaicin microemulsion is suitable and shows potential transdermal delivery system.

关 键 词：辣椒碱 微乳 颜色分析 皮肤刺激性 透皮给药系统 

分 类 号：R927.1[医药卫生—药学]