HIFU联合SonoVue损伤含较大血管肝组织的实验研究  

The experimental study of HIFU with SonoVue damaging the liver tissues containing large blood vessels

作　　者：秦艳[1] 李全义[1] 王琦[1] 龚晓波[1] 李发琪[1] 白晋[1] 

机构地区：[1]重庆医科大学生物医学工程系重庆市生物医学工程学重点实验室重庆市超声医学工程重点实验室-省部共建国家重点实验室培育基地,重庆400016

出　　处：《重庆医科大学学报》2009年第4期439-442,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金重点项目(30830040);重庆市科委自然科学基金重点项目(CSTC2006BA5020);重庆市科委攻关项目(渝科发计字[2007]11号CSTC2007AA5020)资助。

摘　　要：目的:探讨HIFU联合SonoVue辐照含有较大血管的靶组织时形成损伤的情况。方法:采用JC型聚焦超声肿瘤治疗系统,对10只南江黄羊正常肝脏进行直线扫描,选择含有3mm血管肝脏组织作为靶区,试验组HIFU辐照前静脉注射SonoVue,对照组不注射SonoVue。于治疗24h后过量麻药处死动物,测量肝脏损伤长、宽以及厚,比较有SonoVue组和无SonoVue组凝固性坏死出现率以及凝固性坏死体积有无差异。结果:损伤深度为30mm,靶组织内含有3mm血管时,HIFU联合SonoVue能够有效的形成损伤,有SonoVue组和无SonoVue组凝固性坏死出现率以及凝固性坏死体积存在差异,差异有统计学意义(P<0.05)。结论:当靶组织内含有较大血管时,SonoVue能够提高HIFU治疗效率,有效的形成损伤。Objective： To study the formation of lesions, caused byHIFU with SonoVue, in liver tissues containing blood vessels with the diameter of about 3mm. Methods： The livers of ten goats were insonicated linearly by Model--JC focused ultrasound tumour therapeutic system.The target regions contained blood vessels with the diameter of about 3mm ,with or without SonoVue.24 hours after the insonication, the goats were executed with overdosage anesthetics.The length, width and thickness of the lesions were measured, then the necrosies volumes with and without SonoVue were compared. Results： When the depth was 30mm,and the target regions caotained large blood vessels, HIFU with SonoVue could form lesions effectively.There was difference of necrosis volumes between lesions with and without SonoVue, and the difference was significant（P〈0.05 ）. Conclusions ： When the target tissues contain large vessels , SonoVue can increase the efficacy of HIFU, and form lesions effectively.

关 键 词：高强度聚焦超声 增效 SONOVUE 血管 肝脏 

分 类 号：R454.3[医药卫生—治疗学]