紫外光谱法测定齐墩果酸缓释滴丸药物含量及体外释放度  

UV determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate

作　　者：李必波[1] 赵领[1] 张雪梅[1] 钟晓东[1] 梁艳[1] 余瑜[1] 

机构地区：[1]重庆医科大学药学院药物化学与生物材料研究室重庆高校药物工程研究中心,重庆400016

出　　处：《重庆医科大学学报》2009年第4期447-451,共5页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(30772595)。

摘　　要：目的:建立紫外光谱法测定齐墩果酸缓释滴丸药物含量及体外释放度。方法:采用尤尼柯UV-2102PCS型紫外可见分光光度计,在207nm波长处,测定齐墩果酸缓释滴丸的药物含量及体外释放度。结果:含量测定时,齐墩果酸在20～80μg/ml范围内,线性关系良好r=0.9995(n=7),回收率在98%～102%之间,RSD<1%(n=3);释放度测定时,齐墩果酸在10～70μg/ml范围内,线性关系良好r=0.9997(n=7),回收率在98%～102%之间,RSD≤1%(n=3)。结论:该测定方法简便、快速,结果准确可靠、重现性好,可作为该制剂的质量控制方法。Objective： To establish UV method for the determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate. Methods： In 207 nm wavelength, the content of sustained-release dropping pills of oleanolic acid and its dissolution rate were determinated by unico UV-2102PCS. Results ： During the determination of the content,the calibration curves was linear in the concentration range of 20 - 80μg/ml, r= 0.9995 （n=7）, The recovery rate was 98.0% - 102%, RSD 〈1%（n=3 ）;during determining the dissolution rate , linearity was good within the concentration range of 10 - 70 μg/ml, r= 0.9997 （n=7）.The recovery rate was 98.0 % - 102%, RSD ≤ 1% （n=3）. Conclusion： The method is simple and rapid, and the results is accurate, reliable, and reproducible. It can be used to control the quality of sustained-release dropping pills of oleanolic acid with satisfactory results.

关 键 词：齐墩果酸 缓释滴丸 含量测定 释放度 

分 类 号：R944.9[医药卫生—药剂学]