丙酸氯倍他索脂质体的药效和安全性评价  

Pharmacodynamics and safety evaluation of clobetasol propionate liposomes

作　　者：谭敏[1] 胡敢[1] 王昆 

机构地区：[1]重庆医科大学附属第二医院皮肤科,重庆400010 [2]重庆科美药友公司,重庆401121

出　　处：《重庆医科大学学报》2009年第4期463-465,共3页Journal of Chongqing Medical University

基　　金：重庆市科技攻关计划项目(编号:CSTC,2006AB5011)。

摘　　要：目的:考察丙酸氯倍他索(Clobetasol propionate liposomes,CP)脂质体对豚鼠慢性湿疹模型的疗效,并进行安全性评价。方法:采用小剂量二硝基氯苯(Dinitrochlorobenzene)反复刺激豚鼠右耳建立豚鼠慢性皮炎湿疹模型;外用CP脂质体、CP乳膏、空白脂质体和生理盐水,2次/d,连用14d,以真皮炎症细胞计数和两耳肿胀度差值为指标,反映CP脂质体对湿疹模型的疗效。豚鼠右侧腹分别给予CP脂质体和CP乳膏,1次/d,连续8周,计算并比较各组表皮细胞层数,评价其安全性。结果:脂质体能有效减少真皮内浸润的炎细胞数量和耳朵肿胀度。该制剂连续应用8周,不引起表皮细胞层数减少。结论:CP脂质体较传统CP乳膏疗效更好,安全性更高。Objective：To investigate pharmacodynamics and safety of clobetasol propionate （CP） liposomes on guinea pigs with chronic dermatitis-eczema.Methods ： Right ears of guinea pigs were repeatedly challenged with a small dose of dinitrochlorobenzene （ DNCB ） for the establishment of model of chronic dermatitis-eczema. The curative effect of CP liposomes was evaluated by cellular infiltrates in dermis and ear swelling thickening. Guinea pigs were given CP liposomes and CP cream on the right abdominal once a day for eight weeks, and the epidermal cell layers was calculated and compared.Results ： CP liposomes could effectively reduce the number of cellular infiltrates in dermis and ear swelling thickening.This preparation for the application of eight weeks did not cause reduction of epidermal cells layers. Conclusion： CP liposomes is more effective on guinea pigs model of chronic dermatitis-eczema with less side effects.

关 键 词：丙酸氯倍他索 脂质体 慢性皮炎-湿疹 

分 类 号：R758.23[医药卫生—皮肤病学与性病学] R965[医药卫生—临床医学]