米非司酮对早孕妇女血清层粘连蛋白及Ⅳ型胶原纤维的影响  

Effects of mifepristone on laminin and collagen Ⅳ in early pregnant women

作　　者：王玉贤[1] 韩周红[1] 土增荣[1] 

机构地区：[1]山西医科大学第一临床医学院妇产科,太原030001

出　　处：《山西医科大学学报》2009年第4期363-365,共3页Journal of Shanxi Medical University

摘　　要：目的探讨服用米非司酮后早孕妇女血清层粘连蛋白(LN)和Ⅳ型胶原纤维(Ⅳ.C)水平变化及其意义。方法采用放射免疫分析法对20例早孕妇女口服米非司酮前后血清中LN和Ⅳ.C进行检测。结果20例早孕妇女口服米非司酮后血清中LN的含量[(78.78±27.00)ng/ml]高于服药前[(70.04±21.79)ng/ml,P<0.05];服药后血清中Ⅳ.C的含量[(35.20±12.58)ng/ml],与服药前[(36.03±12.30)ng/ml]比较,差异无统计学意义(P=0.578)。结论口服米非司酮可使早孕妇女血清中LN的含量升高,而对Ⅳ.C的含量无影响。LN可能参与米非司酮引起的流产机制,并在早期妊娠的持续中起重要的作用。Objective To explore the effect of mifepristone on the serum levels of laminin （ LN）, collagen Ⅳ and its significance. Methods Twenty early pregnant women were enrolled for the study. The serum levels of LN and collagen Ⅳ were determined before and after treated with mifepristone. Results After treatment, the mean value of LN in serum was （ 78.78 ± 27.00 ） ng/ml, significantly higher than that before treatment[ （70.04± 21.79） ng/ml,P 〈0.05 ]. The mean value of collagen Ⅳ in serum of early pregnant women was lower after treatment than that before treatment[ （35.20 ± 12. 58） ng/ml vs （36.03 ± 12.30） ng/ml ] ,but there was no significant difference. Conclusion Mifepristone can elevate the levels of LN in women with early pregnancy,but have no effect on the levels of collagen IV in women with early pregnancy. LN may be responsible for the early pregnancy, and may take part in the abortion mecha- nism of mifepristone.

关 键 词：米非司酮 早孕 层粘连蛋白 IV型胶原纤维 

分 类 号：R714.21[医药卫生—妇产科学]