Novel,efficient,and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr_2 in aqueous media  

作　　者：Shivaji S.Pawar Murlidhar S.Shingare Shivaji N.Thore 

机构地区：[1]Department of Chemistry,Vinyakrao Patil Mahavidyala Vaijapur [2]Department of Chemistry,Dr.Babasaheb Ambedkar Marathwada University

出　　处：《Chinese Chemical Letters》2009年第1期32-36,共5页中国化学快报（英文版）

摘　　要：MgBr2 performs as a novel catalyst for the synthesis of various 1,5-benzodiazepine derivatives from wide range of substituted o- phenylenediamines and various ketones in good to excellent isolated yields （93-98%） using water as solvent at ambient temperature. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster （40-60 man） reactions and good to excellent yields of products.MgBr2 performs as a novel catalyst for the synthesis of various 1,5-benzodiazepine derivatives from wide range of substituted o- phenylenediamines and various ketones in good to excellent isolated yields （93-98%） using water as solvent at ambient temperature. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster （40-60 man） reactions and good to excellent yields of products.

关 键 词：MgBr2 O-PHENYLENEDIAMINES KETONES Aqueous media 1 5-Benzodiazepine 

分 类 号：O621.251[理学—有机化学]