子痫前期患者脐血流与围产儿结局的相关性研究  

Relationship between preeclampsia umbilical blood flow and perinatal outcomes

作　　者：陈洁[1] 余艳红[1] 王志坚[1] 秦薇[2] 张庆 

机构地区：[1]南方医科大学南方医院妇产科,广东广州510515 [2]深圳市妇幼保健院产二区,广东深圳518028 [3]深圳市龙岗区坪地人民医院,广东深圳518117

出　　处：《南方医科大学学报》2009年第4期745-746,750,共3页Journal of Southern Medical University

基　　金：广东省自然科学基金(5004744)

摘　　要：目的探讨子痫前期患者脐动脉血流改变与围产儿结局的相关性。方法观察记录106例子痫前期患者的脐动脉血流参数S/D值、搏动指数(PI)、阻力指数(RI)及新生儿出生时平均体质量、Apgar评分及胎盘重量变化等,分析血流参数与围产儿结局的相关性。结果(1)随着子痫前期病情严重程度的增加,S/D、PI、RI均呈增高趋势,重度子痫前期比值明显高于正常组,统计结果有显著性差异(P<0.01),轻度子痫前期组与正常组比较增高趋势不明显,无显著性差异(P>0.05);(2)随着脐血流比值的增加,重度子痫前期的新生儿出生时平均体重、Apgar评分、胎盘重量均低于正常组,统计结果有显著性差异(P<0.01),FGR发生率、围产儿死亡率明显高于正常组,统计结果有显著性差异(P<0.01),但上述变化在轻度子痫前期组表现不为显著。结论脐血流S/D、PI、RI值可以作为判断胎儿宫内状况的指标,为胎儿预后提供了一种监测手段。Objective To study the relationship between preeclampsia umbilical blood flow changes and the pregnancy outcomes. Methods The umbilical arterial blood flow parameters including the S/D, pulsatility index （PI）, resistance index （RI） and the average birth weight, Apgar score and placental weight changes were analyzed in 106 preeclampsia patients （including 43 mild and 63 severe cases）, with 89 women with normal pregnancy as the control. The relation between the blood flow parameters and the perinatal outcomes were analyzed. Results S/D, PI, and RI all tended to increase with the severity of preeclampsia, and these indices were significantly higher in patients with severe preeclampsia than in the control group （P〈0.01） but showed no significant differences between mild preeclampsia group and the control group （P〉0.05）. The average birth weight of the newborns, Apgar scores, and placental weight were significantly lower （P〈0.01）, and the incidence of fetal growth restriction （FGR） and perinatal mortality significantly higher in severe preeclampsia group than in the control group （P〈0.01）. No significant differences were found in these parameters between the mild preeclampsia and the control groups （P〉0.05）. Conclusion Umbilical artery blood flow parameters as indicators for determining the fetal status can be used to nredict the pregnancy outcomes.

关 键 词：彩色多普勒超声 子痫前期 脐动脉血流比值 围产儿结局 

分 类 号：R714.7[医药卫生—妇产科学]