枸杞提取物对小鼠抗疲劳作用的实验研究  

Study on the Anti-Fatigue Effect of extract of Chinese wolfberry in mice

作　　者：覃筱燕[1] 唐丽[1] 杨林[1] 戴景峰[1] 黄菊阳[1] 常嘉[1] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081

出　　处：《中医药学报》2009年第2期8-10,共3页Acta Chinese Medicine and Pharmacology

基　　金：教育部人文社会科学重点研究基地2007年重大研究资助项目(07JJD850211);985工程资助项目(CUN985-03-03)

摘　　要：目的:观察枸杞提取物的抗疲劳作用,为临床用药提供实验依据。方法:1.以不同浓度的枸杞提取物(5mg/kg、10mg/kg、20mg/kg)对小鼠进行灌胃饲养,采用游泳法观察药物的抗疲劳作用;2.进行小鼠的爬杆实验,记录3次跌落时间并相加作为该鼠的总时间,观察小鼠的抗疲劳性;3.称量小鼠的肝脏,间接显示枸杞提取物提高肝糖原的含量从而提高能量的贮备达到抗疲劳的作用。结果:小鼠在30℃的温水浴中负重游泳,实验组小鼠的游泳时间明显长于对照组小鼠;小鼠爬杆实验中,实验组小鼠的爬杆时间明显长于对照组的爬杆时间;并且称量小鼠肝重,实验组与对照组有明显增加;实验结果无明显剂量关系,以中剂量组(10mg/kg)抗疲劳作用更为显著。结论:枸杞提取物具有显著的抗疲劳作用。Objective:To investigate the Extract of Chinese wolfberry for an Anti-Fatigue Effect,using clinical medication for experimental basis.Methods:1.Different concentrations of Chinese wolfberry extract(5mg/kg、10mg/kg、20mg/kg)on mice gavage feeding,swimming was observed by the anti-drug role of fatigue;2.Observing the anti-fatigue effect through the climb-mouse experiment,record the time and dropped three times as the sum of the total time on mice;3.Weighing liver of mice,indirectly show that wolfberry extract of the glycogen increase in the reserve so as to enhance energy to the role of anti-fatigue.Results:Mice in a water bath temperature of 30℃ loaded swimming in the experimental group of mice swim time was longer than the control group mice;Climbing-mouse experiments,the experimental group of mice crawling at the time was longer than the control group at the time to climb;re-weighing mouse liver the experimental group and control group have increased significantly;experimental results don't show dose-depended relation,middle concentrations of Chinese wolfberry extract for Anti-Fatigue Effect have more increased significantly.Conclusion:Extract of Chinese wolfberry had a significant Anti-Fatigue Effect.

关 键 词：枸杞提取物 抗疲劳作用 

分 类 号：R285.5[医药卫生—中药学]